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Rifaximin Treatment Period According to Lactulose Breath
? 2015 The Korean Academy of Medical Sciences.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (/licenses/by-nc/4.0)
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
pISSN 1011-8934
eISSN 1598-6357
Determination of Rifaximin Treatment Period According to
Lactulose Breath Test Values in Nonconstipated Irritable Bowel
Syndrome Subjects
Small intestinal bacterial overgrowth (SIBO) can partly explain irritable bowel syndrome
(IBS), and rifaximin has been observed to improve abdominal symptoms in nonconstipated
IBS patients. However, there are few reports on the association of the rifaximin treatment
periods with the results of a lactulose breath test (LBT). Therefore, we performed a
retrospective review of patient charts to investigate the relation between the rifaximin
treatment periods with LBT results in nonconstipated IBS patients. We also evaluated the
time to achieve a symptomatic improvement in the IBS patients as compared to the
changes in the LBT. We reviewed the charts for patients who showed IBS symptoms with
documented positive results for LBT during their initial visit and who had a follow-up LBT
after treatment with rifaximin. The LBT values were compared to the subjects’ symptom
scores. A total of 102 subjects had a follow-up LBT to assess LBT normalization. The
subjects were divided into groups according to treatment periods of 4 weeks (n = 36),
8 weeks (n = 43), and 12 weeks (n = 23). The groups with a longer treatment exhibited an
increase in the hydrogen gas value at 90 min and its sum during 90 min at the initial LBT.
There were significant differences in hydrogen gas value at 90 min and in its sum during 90
min at the initial LBT between the groups treated for 4 and 12 weeks. The most significant
treatment response was observed during the first 4 weeks for all treatment g
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