乳糖喷雾干燥Laboratory Scale Spray Drying of Lactose.pdf

en @buchibest Laboratory Scale Spray Drying of Lactose: A Review Information Bulletin Number 57/2010 Lactose Dry Powder Inhalation be st@ bu ch i 5 7/ 20 10 e n The adjustable spray drying process parameters: ? inlet and outlet temperature, ? sample feed rate, ? drying gas flow rate and ? spray gas flow In the presented research studies (see Table 4), the inlet air temperatures ranged Author: Dr. Cordin Arpagaus, Dr. Nina Schafroth and Marco Meuri Introduction Spray drying is a commonly practiced method to prepare inhalable powders. This study reviews recently published scientific work in the field of lactose spray drying for inhalable applications using BüCHI laboratory scale spray dryers. The generations of the Mini Spray Dryer; B-190, B-191 and B-290 models and the new Nano Spray Dryer B-90 are illustrated in Figure 1. Laboratory Scale Spray Drying of Lactose: A Review from 90 °C to 210 °C depending on the application, the feed rate was set between 2 mL/min to 15 mL/min, the drying gas flow rate was set typically to 40 m3/h and the spray gas was 300-700 L/h. Mainly aqueous solutions were prepared by dissolving an active ingredient (drug, nanoparticles) and excipient (lactose and others) in water at different solid concentrations. In some studies ethanol was added to the solution to enhance evaporation [3, 5, 7, 8]. The sample volume varied between 50 and 450 mL. The resultant spray dried powder was separated by a cyclone and collected in a vessel. The exhaust gas was extracted from the cyclone and filtered. In contrast, the new Nano Spray Dryer B-90 is based on a new spray drying concept, as illustrated in Figure 3. A comparison with the traditional Mini Spray Dryer B-290 is given in Table 1. The drying gas enters the apparatus from the top where it is heated to the set inlet temperature, flows then through the drying chamber, and exits the spray dryer F