- 1、本文档共5页,可阅读全部内容。
- 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
16.Effects of candesartan in patients with chronic heart failure
For personal use. Only reproduce with permission from The Lancet publishing Group.
ARTICLES
THE LANCET ? Vol 362 ? September 6, 2003 ? 777
Summary
Background Half of patients with chronic heart failure (CHF)
have preserved left-ventricular ejection fraction (LVEF), but
few treatments have specifically been assessed in such
patients. In previous studies of patients with CHF and low
LVEF or vascular disease and preserved LVEF, inhibition of
the renin-angiotensin system is beneficial. We investigated
the effect of addition of an angiotensin-receptor blocker to
current treatments.
Methods Between March, 1999, and July, 2000, we
randomly assigned 3023 patients candesartan (n=1514,
target dose 32 mg once daily) or matching placebo
(n=1509). Patients had New York Heart Association
functional class II–IV CHF and LVEF higher than 40%. The
primary outcome was cardiovascular death or admission to
hospital for CHF. Anaysis was done by intention to treat.
Findings Median follow-up was 36·6 months. 333 (22%)
patients in the candesartan and 366 (24%) in the placebo
group experienced the primary outcome (unadjusted hazard
ratio 0·89 [95% CI 0·77–1·03], p=0·118; covariate adjusted
0·86 [0·74–1·0], p=0·051). Cardiovascular death did not
differ between groups (170 vs 170), but fewer patients in the
candesartan group than in the placebo group were admitted
to hospital for CHF once (230 vs 279, p=0·017) or multiple
times. Composite outcomes that included non-fatal
myocardial infarction and non-fatal stroke showed similar
results to the primary composite (388 vs 429; unadjusted
0.88 [0·77–1·01], p=0·078; covariate adjusted 0·86
[0·75–0·99], p=0·037).
Interpretation Candesartan has a moderate impact in
preventing admissions for CHF among patients who have
heart failure and LVEF higher than 40%.
Lancet 2003; 362: 777–81. Published online Sept 1, 2003
/extras/03art7419web.pdf
See Commentary page 754
Introduction
Around 50% of patients with chronic heart failure (CHF)
do not have low lef
您可能关注的文档
- %Krause ICML2010 - Submodular dictionary selection for sparse representation.pdf
- (ISP图的画法可参考)等电点沉淀法回收蛋白的特性.pdf
- (MX-GC控制柜)).pdf
- (ppt) IBM Content Based Copy Detection System for TRECVID 2009.pdf
- (ppt)BEA Weblogic Server8.1 Web Service.pdf
- (Reactive Violet 5R) decolorising native acclimatised bacterial consortia.pdf
- (universal.pdf
- (全6章)HL7 v3基础 Foundation完整版.pdf
- (初三英语测试题二).doc
- (天泉多级泵样本)TDLF-27p.pdf
- 英语人教PEP版八年级(上册)Unit4+writing+写作.pptx
- 人美版美术四年级(上册)8 笔的世界 课件 (1).pptx
- 人美版美术七年级(上册)龙的制作.pptx
- 英语人教PEP版六年级(上册)Unit 2 第一课时.pptx
- 数学苏教版三年级(上册)3.3 长方形和正方形周长的计算 苏教版(共12张PPT).pptx
- 音乐人教版八年级(上册)青春舞曲 课件2.pptx
- 音乐人教版四年级(上册) 第一单元 音乐知识 附点四分音符|人教版.pptx
- 英语人教PEP版四年级(上册)Unit 6 Part B let's learn 1.pptx
- 道德与法治人教版二年级(上册)课件-3.11大家排好队部编版(共18张PPT).pptx
- 人美版美术七年级(上册)《黄山天下奇》课件1.pptx
文档评论(0)