3D PLLA-nano-hydroxyapatite scaffolds with hierarchical porous structure fabricated by low-tempera.pdf

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3D PLLA-nano-hydroxyapatite scaffolds with hierarchical porous structure fabricated by low-tempera.pdf

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3D PLLA-nano-hydroxyapatite scaffolds with hierarchical porous structure fabricated by low-tempera

Journal of Wuhan University of Technology-Mater. Sci. Ed. Apr.2012 265 3D PLLA/Nano-hydroxyapatite Scaffolds with Hierarchical Porous Structure Fabricated by Low- temperature Deposition Manufacturing LIANG Yingchun, ZHENG Xiongfei*, ZHAI Wenjie, SUN Tao (Precision Engineering Research Institute, Harbin Institute of Technology, Harbin 150001, China) Abstract: A new Precision Extrusion nozzle based ball screw transmission was developed. 3D hierarchical porous PLLA/nano-Hydroxyapatite(PLLA/nHA) scaffolds were fabricated by low-temperature deposition manufacturing. Scaffolds with macropores of 200-500 μm and micropores about 10 μm were fabricated through a thorough study and control of the processing parameters, in which the processing path and speed of material extrusion determine the macropores and there is a suitable temperature zone for fabricating qualifi ed macropores. Micropore morphology can be controlled by adjusting supercooling of solvent crystallization or adding water into the solvent system. The compressive modulus of the scaffolds in air and phosphate buffer solution was measured, which increased with HA addition. In-vitro cell culture results showed a good biocompatibility of PLLA/HA scaffolds with the pre-osteoblastic MC3T3-E1 cells. Key words: tissue engineering; rapid prototyping; low-temperature deposition; scaffold; PLLA; nano- hydroxyapatite ?Wuhan University of Technology and SpringerVerlag Berlin Heidelberg 2012 (Received: Oct. 15, 2010; Accepted: Feb. 18, 2011) LIANG Yingchun(梁迎春): Prof.; E-mail: ycliang@ *Corresponding author: ZHENG Xiongfei(郑雄飞): Ph D; E-mail: jimmyfigo@163.com Fund by the Harbin Science and Technology Innovation Researchers Project(No. 2007RFXXSO21) DOI 10.1007/s11595-012-0450-2 1 Introduction Tissue engineering is an interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue fu