Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea.pdf

PO Box 2345, Beijing 100023, China World J Gastroenterol 2006 February 14; 12(6): 951-955 World Journal of Gastroenterology ISSN 1007-9327 wjg@ ? 2006 The WJG Press. All rights reserved. Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea Hansoo Kim, Hyo-Jong Kim, Sung-Gil Chi, Sang-Kil Lee, Gwang-Ro Joo, Seok-Ho Dong, Byung-Ho Kim, Young-Woon Chang, Jung-Il Lee, Rin Chang Hansoo Kim, Hyo-Jong Kim, Sang-Kil Lee, Gwang-Ro Joo, Seok-Ho Dong, Byung-Ho Kim, Young-Woon Chang, Jung- Il Lee, Rin Chang, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea Sung-Gil Chi, Department of Bioscience, College of Life Sciences, Korea University, Seoul, Korea Correspondence to: Dr. Hyo-Jong Kim, Department of Medicine, Kyung Hee University School of Medicine, #1 Hoegi-Dong, Dongdaemun-Gu, Seoul 130-702, Korea. hjkim@khmc.or.kr Telephone: +82-2-958-8200 Fax: +82-2-968-1848 Received: 2005-03-17 Accepted: 2005-06-18 Abstract AIM: Recently, germ-line mutation in the base excision repair gene MYH has been identifi ed to cause a novel autosomal recessive form of familial adenomatous polyposis (FAP). Interestingly, a striking evidence for MYH mutations within different ethnic groups has been demonstrated. In this study, we screened 30 patients with multiple adenomatous polyps for MYH mutations to assess its prevalence and ethnic specifi city in Korea. METHODS: Thirty patients (21 men and 9 women; mean age 62.3 years) with multiple adenomatous polyps were examined for MY