anie_200900212_sm_miscellaneous_information.pdf

  1. 1、本文档共47页,可阅读全部内容。
  2. 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
anie_200900212_sm_miscellaneous_information

Supporting Information ? Wiley-VCH 2009 69451 Weinheim, Germany S 1 A Novel Multicomponent Reaction of Arynes, Isocyanides, and Terminal Alkynes: Highly Chemo- and Regioselective Synthesis of Polysubstituted Pyridines and Isoquinolines Feng Shaa, Xian Huang* a, b a. Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, P. R. China b. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China huangx@mail.hz.zj.cn Supporting Information List of contents Experiment procedures……………………………………….……S2-S4 Characterization data: 4a-b and 6a-l…………………………………………………….S5-S9 5a-f and 5g-i……………………………………………………S10-S13 1H NMR and 13C NMR spectra………………………………….S14-S37 2D 1H-1H NOESY spectra………………………………………S38-S46 S 2 1. Experiment procedures All reactions were performed under a purified N2 atmosphere. Dry solvents were distilled prior to use: THF, Et2O, and toluene were distilled from sodium-benzophenone; MeCN were distilled from P2O5; CH2Cl2 was distilled from CaH2. Petroleum ether refers to the fraction with boiling point in the range 60 – 90 °C. All 1H NMR and 13C NMR spectra were measured in CDCl3 with TMS as the internal standard. Chemical shifts are expressed in ppm and J values are given in Hz. Melting points are uncorrected. 2-(Trimethylsilyl)aryl triflates 1 were prepared according to the known methods.1 General Procedure 1.1.1 Multicomponent reaction of 2-(trimethylsilyl)aryl triflates 1, isocyanides 2, and terminal alkynes 3 leading to polysubstituted pyridines 6a-k To a stirred solution of 2-(trimethylsilyl)aryl triflate 1 (0.65 mmol), isocyanide 2 (0.5 mmol), and terminal alkyne 3 (1.5 mmol) in dry MeCN (0.5 mL) and dry toluene (2 mL), CsF (1.3 mmol, 198 mg) was added under nitrogen atmosphere. The reaction mixture was then allowed to stir at 75 o

文档评论(0)

l215322 + 关注
实名认证
内容提供者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档