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Antihemophilic factor plasma albumin free method for the management and prevention of
? 2009 Pipe, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which
permits unrestricted noncommercial use, provided the original work is properly cited.
Biologics: Targets Therapy 2009:3 117–125 117
R E V I E W
Antihemophilic factor (recombinant)
plasma/albumin-free method for the management
and prevention of bleeding episodes in patients
with hemophilia A
Steven Pipe
Department of Pediatrics
and Communicable Diseases, University
of Michigan, Ann Arbor, MI, USA
Correspondence: Steven W Pipe, MD
Department of Pediatrics
and Communicable Diseases, University
of Michigan, 1500 East Medical Center
Drive, Ann Arbor, Michigan 48109, USA
Tel +1 734 647 2893
Fax +1 734 936 7083
Email ummdswp@med.umich.edu
Abstract: Hemophilia is a rare genetic bleeding disorder that, if not adequately controlled, is
associated with life-threatening bleeding events and serious and costly complications, primarily
from joint damage. The advent of effective clotting factor replacement therapy for patients
with hemophilia is considered one of the foremost medical advances of the 20th century. The
last 3 decades of experience in hemophilia care have witnessed the effectiveness of the care
of patients with hemophilia within specialized comprehensive care centers, advances in factor
replacement therapies, the benefi ts of prophylaxis over on-demand replacement therapy, and
the role of aggressive management of joint disease to prevent dysfunction. Ongoing challenges,
including the management of inhibitors to factor therapies and the consequences of thousands
of patients with hemophilia becoming infected with human immunodefi ciency virus and
hepatitis C virus in the 1980s from contaminated plasma-derived factor concentrates, have
highlighted the need for vigilance with respect to clotting factor product safety, access to care,
and a full complement of choice of factor replacement therapies. Advate? (antihemophilic
factor [recombinant] plasma/albu
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