Chemically modified light-curable chitosans with enhanced.pdf

Chemically modified light-curable chitosans with enhanced.pdf

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Chemically modified light-curable chitosans with enhanced

Chemically modified light-curable chitosans with enhanced potential for bone tissue repair Yongzhi Qiu,1 Ning Zhang,1,2 Qian Kang,3 Yuehuei An,3 Xuejun Wen1–3 1Clemson-MUSC Bioengineering Program, Department of Bioengineering, Clemson University, Charleston, South Carolina 29425 2Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425 3Department of Orthopedic Surgery, Medical University of South Carolina, Charleston, South Carolina 29425 Received 9 September 2007; revised 12 December 2007; accepted 8 February 2008 Published online 8 May 2008 in Wiley InterScience (). DOI: 10.1002/jbm.a.32017 Abstract: Light curable polymers are showing great potential in overcoming some of the current obstacles in bone repair. With stereolithography, they can be fabricated into scaffolds with desired topography for repairing bone defects in irregular shapes. In this study, we developed a series of light curable chitosans, which have photocurabil- ity and good solubility in organic solvent. Through adjust- ing the feeding ratio of the raw components, the content of photocurable groups in the backbone of chitosan can be controlled. The light curable chitosans were characterized through FTIR–ATR and 1H NMR, which also confirmed their controllable photocurability. NIH 3T3 fibroblasts were co-cultured with the photocured samples for 7 days and the results indicated that these photocured chitosans are cyto-compatible. Scaffolds with interconnected pores, fabricated using salt leaching and photocuring and seeded with fetal bovine osteoblasts, were implanted subcutane- ously in the backs of athymic rat. Histological study on the implants at 6 weeks showed that the photocured chitosans have good osteoconductivity. The results indicated the light curable chitosans have good biocompatibility and osteoconductivity.  2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 772–779, 2009 Key words: light curable; chitosan; osteoconductivity; bo

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