Cutometer皮肤弹性分析方法的开发与应用.pdf

Cutometer皮肤弹性分析方法的开发与应用 Development and Application of Novel Viscoelastic Parameters in Cutometer Di Qu，Ph．D．，Jesse C．Leverett，James R．Mayne， G Paul Seehra，Ph．D．，John V．Scimeca，Bill M．Luke，and Fiona Fu (Center for Skin Health Research，Amway Corporation， 7575 Fulton Street East，Ada，MI 49355．U．S．A．) 摘要：日的．开发一种新的Cutometer数据分析方法，并用于定量评估皮肤弹性变化。方法一针对 Cutometer测量皮肤弹性传统分析方法的不足，开发一种新的分析方法，该方法采用刚折点及面积参数 定义皮肤弹性特性，分别为粘弹性恢复参数(ⅣR0)，弹性恢复参数(R胡R0)及粘性恢复参数(Rv／R0)；应 用新的分析方法在69名健康女性测试者中观察年龄对皮肤弹性的影响，并定最评估抗哀老产品功效。 结果-年龄增长对皮肤粘性没有影响，但可降低皮肤的粘弹性及弹性，且呈明显的线性关系。应用皮 肤弹性新参数，本研究组建立了一组联系皮肤弹性与年龄的标准曲线，可定量评估抗衰老产品功效。应 用新方法分析发现，涂抹抗衰老产品(9295．04和9295—05)六岗后皮肤弹性参数有显著改善。参照皮 肤年龄一弹性曲线硅示，此变化相当于平均皮肤年龄减少约15年。结论．本研究组开发的Cutometer分 析方法可人人提高皮肤弹性测量的精确度，能更准确地定量评估皮肤弹性特性。 关键词：Cutometer；皮肤：粘弹性：弹性：年龄：功效 Abstract：Biological age and anti—aging product efficacy were evaluated in human skin in vitro using novel viscoelastic parameters．The Cutometer SEM 575(CK Electronics)Was employed to collect the mechanical responses of the skin．Measurements were conducted on the inner forearm skin of sixty—nine healthy female volunteers age 1 8 to 60 years．Cutometer data were then analyzed using an automated technique of inflection point and area analysis to obtain novel viscoelastic parameters termed total viscoelastic recovery (R／Ro)，elastic recovery(R^)，and“viscous”recovery(Rv／R o)·Our results showed strong correlation of age with two skin viscoelastic parameters——viscoelastic and elastic recovery．Age did not seem tO affect the viscous component although a slight declining trend was observed．Standard curves were constructed based on those parameters tO provide linear age—elasticity functions for quantification of product efficacy．A 6 week anti-aging product efficacy trial Was then conducted on 30 volunteers tO evaluate the biomechanical properties of skin．At the end of the trial，significant improvement in viscoelastic and elastic parameters were observed when compared to baseline．Average elastic improvement at 6 weeks corresponded to app