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DDDT-10044-development-of-a-sublingual-allergy-vaccine-for-grass-pollin_061510
? 2010 Frati et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article
which permits unrestricted noncommercial use, provided the original work is properly cited.
Drug Design, Development and Therapy 2010:4 99–105
Drug Design, Development and Therapy Dovepress
submit your manuscript |
Dovepress
99
R e v i e w
open access to scientific and medical research
Open Access Full Text Article
10044
Development of a sublingual allergy vaccine
for grass pollinosis
Franco Frati1,2
Silvia Scurati1
Paola Puccinelli1
Marie David3
Cecile Hilaire4
Maurizio Capecce4
Francesco Marcucci2
Cristoforo incorvaia5
1Medical and Scientific Department,
Stallergenes, Milan, italy; 2University
Department of Medical and Surgical
Specialties and Public Health, Perugia,
italy; 3Laboratoire Stallergenes,
Antony, France; 4Marketing
Department, Stallergenes, Milan, italy;
5Allergy/Pulmonary Rehabilitation
Unit, iCP Hospital, Milan, italy
Correspondence: Cristoforo incorvaia
Allergy/Pulmonary Rehabilitation Unit,
iCP Hospital, via Bignami 1, Milan, italy
Tel +39 025 799 3289
Fax +39 025 799 3315
email cristoforo.incorvaia@
Abstract: Grass pollen is a very common cause of allergic rhinitis and asthma. The only
treatment targeting the underlying causes of allergy is immunotherapy (IT). Sublingual
immunotherapy (SLIT) has been introduced to solve the problem of systemic reactions to
subcutaneous IT (SCIT). This article evaluates the characteristics of the allergen extract,
Staloral, in terms of practical administration, effectiveness, safety, and mechanism of action.
Efficacy data were obtained from double-blind, placebo-controlled studies using Staloral in
patients sensitized to grass pollen, while practical administration, cost-effectiveness, and
mechanism of action data were provided by well designed studies. The efficacy and safety of
Staloral, as demonstrated by review of published studies which used doses up to 1125 times
those administe
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