Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients wi.pdf

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Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients wi.pdf

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Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients wi

? 2006 The Authors 454 Journal compilation ? 2006 The International Society for Diseases of the Esophagus Diseases of the Esophagus (2006) 19, 454–458 DOI: 10.1111/j.1442-2050.2006.00618.x Blackwell Publishing AsiaOriginal article Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma T. Ando, H. Ishiguro, M. Kimura, A. Mitsui, H. Kurehara, N. Sugito, K. Tomoda, R. Mori, N. Takashima, R. Ogawa, Y. Fujii, Y. Kuwabara Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan SUMMARY. NDRG1 (N-myc downstream regulated gene-1) was reported to be necessary for p53-mediated apoptosis and to be regulated by PTEN (phosphatase and tensin homolog). In several cancers, it was suggested to be a tumor suppressor gene. Its significance in esophageal squamous cell carcinoma (ESCC) has not been studied. The objective of this study was to clarify the relation between clinicopathological and biologic factors in esophageal carcinoma and to determine the prognostic significance of the expression of NDRG1. Expression of NDRG1 mRNA was quantified by real-time reverse transcription polymerase chain reaction using a Lightcycler in 47 esophageal ESCC specimens. The data were analyzed with reference to clinicopathological factors. Among the esophageal cancer tissues, NDRG1 mRNA expression was significantly lower in tumors of more advanced pathological stage (0–I vs. II–IV; P = 0.0027) and local tumor invasion (T1–2 vs. T3–4; P = 0.0136). Patients who had low NDRG1 mRNA expression had a significantly shorter survival after surgery compared with patients who had high NDRG1 mRNA expression (log-rank test, P = 0.0478). Impaired NDRG1 expression may lead to more aggressive invasion of ESCC. KEY WORDS: esophageal squamous cell carcinoma, LightCycler, N-myc downstream regulated gene-1, Realtime PCR. INTRODUCTION Esophageal squamous cell carcinoma (ESCC) is the sixth most common cancer in Japa