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Define and Control Severe Acute
China holds the key to solving many questions crucial
to global control of severe acute respiratory syndrome
(SARS). The disease appears to have originated in
Guangdong Province, and the causative agent, SARS
coronavirus, is likely to have originated from an animal
host, perhaps sold in public markets. Epidemiologic find-
ings, integral to defining an animal-human linkage, may be
confirmed by laboratory studies; once animal host(s) are
confirmed, interventions may be needed to prevent further
animal-to-human transmission. Community seroprevalence
studies may help determine the basis for the decline in dis-
ease incidence in Guangdong Province after February
2002. China will also be able to contribute key data about
how the causative agent is transmitted and how it is evolv-
ing, as well as identifying pivotal factors influencing disease
outcome.
Severe acute respiratory syndrome (SARS) is a newlyemerged disease, caused by a previously unknown
coronavirus. The first known cases occurred in Guangdong
Province in southern China in November and December
2002. During late February 2003, a physician who was
incubating SARS traveled from Guangzhou, the provincial
capital, to Hong Kong, Special Administrative Region of
China, and stayed at a hotel. There, the virus was transmit-
ted from him to local residents and to travelers, who
became ill and transmitted disease to others when they
returned to Vietnam, Singapore, Canada, and Taiwan,
Province of China (1). SARS has now occurred in 8,450
people with 800 deaths worldwide.
The tally of SARS climbed rapidly in China through
May 2003, then decelerated markedly during June. The
disease has now been reported in 24 of China’s 31
provinces. By June 26, 2003, a total of 5,327 SARS cases
and 348 deaths had been reported from mainland China,
including 2,521 cases in Beijing and 1,512 in Guangdong
Province.
Since February 2003, teams of technical consultants for
the World Health Organization have been working in
China to provide as
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