Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin.pdfVIP

One of the proteins identified through this screen was CD44, a cell membrane-bound glyco- protein involved in cell adhesion and migration (38). The spatial organization of CD44 upon ephrin-A1 stimulation was found to antilocalize with the assembly of EphA2 (Fig. 4D), validat- ing the involvement of CD44 in cell-driven EphA2 receptor reorganization. The system- wide correlation analysis does not necessarily provide the mechanistic details leading to EphA2 sorting; instead, it identifies proteins and genes that may serve as surrogate markers to centripetal transport. In conclusion, we report a s