New ultrasmall iron-oxide nanoparticles with high magnetisation as potential T1-MRI contras.pdf
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New ultrasmall iron-oxide nanoparticles with high magnetisation as potential T1-MRI contras
1New ultrasmall iron-oxide nanoparticles with high magnetisation as
potential T1-MRI contrast agents for Molecular Imaging.
aInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Esfera de la UAB,
08193 Bellaterra, Catalunya, Spain
bDepartment of General, Organic and Biomedical Chemistry, NMR and Molecular
Imaging Laboratory, University of Mons-Hainaut, B-7000 Mons, Belgium
* corresponding author: roig@icmab.es
2Abstract
Here we report on the synthesis of very small ?-Fe2O3 nanoparticles (5 nm) presenting very
narrow particle size distribution and exceptionally high saturation magnetisation. The
synthesis has been carried out in an organic medium with subsequent transfer to an
aqueous solution at physiological pH. The structural and magnetic properties were kept
unaltered after the solvent exchange. NMR relaxometric measurements show the potential
of these particles as specific reporters for magnetic resonance molecular imaging.
3Introduction
Magnetic resonance imaging (MRI) is a medical technique widely employed in many
clinical practices due to its capability to enhance contrast differences between healthy and
pathological tissues. Images of body sections precisely reflect the variation in the proton
density, longitudinal or transversal relaxation time, T1 or T2 of the tissues. Despite the
inherent versatility of this imaging modality, researchers and clinicians are dedicating huge
efforts to develop safer and more effective contrast agents (CAs) that will expand the
diagnostic utility and improve the precision of MRI. The main application of CAs relies on
the shortening of the relaxation times of the water protons. Positive contrast agents reduce
T1 resulting in a brighter signal, while negative contrast agents reduce T2 resulting in a
darker signal. The reciprocals of the relaxation times are called the relaxation rates, R1 and
R2, with the effectiveness of a CA expressed as relaxivities, r1 and r2, i.e. the rate(s)
enhancement(s) brou
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