Nucleotide Polymorphism in Clusterin Gene.pdf

Association Analysis Between the rSingle Nucleotide Polymorphism in Clusterin Gene, rs3851179 Single Nucleotide Polymorphism in Clathrin Assembly Lymphoid Myeloid Protein Gene and the Patients with Schizophrenia in the Chinese Population Yi Zhou,1 Jun Wang,1 Kana Wang,2 Siyue Li,1 Xingbo Song,1 Yuanxin Ye,1 Lanlan Wang,1 and Binwu Ying1 Clusterin (CLU) and clathrin assembly lymphoid myeloid (CALM) protein are implicated in the function of neuronal synapses. However, to our knowledge, whether they play roles in the maldevelopment of synaptic pathways in schizophrenia has not been studied. The purpose of this study was to examine whether single nucleotide polymorphisms rwithin the CLU gene and rs3851179 within the CALM gene, were asso- ciated with schizophrenia. Polymorphisms rand rs3851179 were analyzed among 184 Chinese pa- tients with schizophrenia and 162 healthy controls. The high-resolution melting method was used to genotype the two loci. Patients with schizophrenia and with family history showed a significant increase of allele C frequency in rin comparison to normal controls ( p? 0.03). In addition, the C allele frequency was also higher in patients with negative symptoms ( p? 0.04). In contrast, allele and genotype frequencies of rs3851179 did not show significant differences between patients and normal subjects or between patients with different symptoms. The results of this study show that polymorphism of the CLU gene may confer symp- tomatic specificity in schizophrenia, whereas polymorphism of the CALM gene does not affect susceptibility to schizophrenia. Introduction Numerous studies have compellingly demonstrated thatheredity plays a key role in the pathophysiology of schizophrenia. It is thought that 80% of the risk for schizo- phrenia and its wide range of phenotypic expression are due to genetic factors (McGuffin and Gottesman, 1999). The neurodevelopmental hypothesis, one of the prevailing hy- potheses about