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A comparison of effects of sequential transdermal administration.pdf

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A comparison of effects of sequential transdermal administration

Maturitas 53 (2006) 32–38 A comparison of effects of sequential transdermal administration versus oral administration of estradiol plus norethisterone acetate on serum NO levels in postmenopausal women Gulay Kurtay a , Batuhan Ozmen b, ? , Imge Erguder c a Menopause Clinic, Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University, Ankara, Turkey b Reproductive Health and Infertility Clinic, Department of Obstetrics and Gynecology, Faculty of Medicine, Ankara University, Uyum Sit. No. 28, Cayyolu-Konutkent, Ankara, Turkey c Department of Biochemistry, Faculty of Medicine, Ankara University, Ankara, Turkey Received 16 February 2004; received in revised form 22 January 2005; accepted 1 February 2005 Abstract Aim: To compare the effects of sequential transdermal administration versus oral administration of estradiol plus NETA on serum nitric oxide (NO) levels in postmenopausal women (PMW). Materials and methods: Eighty postmenopausal subjects without any prior hormone replacement therapy (HRT) usage were enrolled in this study. All participants were healthy, ambulatory, non-smoker and had similar life styles with dietary habits. HRT was given to participants according to desired HRT administration, in group A (n= 50); oral estradiol hemi-hydrate ( a u t R a B s C c ? K f 02 mg)/norethisterone acetate (1 mg), and in group B (n= 30); transdermal combined patch comprising estradiol (0.05 mg) alone nd estradiol (0.05 mg)/norethisterone acetate (0.25 mg), were given sequential for 12 months. Serum NO levels were studied sing Total Oxide Assay Kit (Assay Designs, Inc.) according to manufacturer’s instructions prior to and after 12 months from he HRT treatment. esults: The mean serum NO levels prior to the HRT in groups A and B was 0.48± 0.46 (range, 0.27–0.76 nmol/mL) nmol/mL nd 0.47± 0.48 nmol/mL (range, 0.29–0.693 nmol/mL) (p 0.05). The mean serum NO levels after the HRT in groups A and was 0.53± 0.33 nmol/mL (range, 0.29–2.10 nmol/mL) and 2.91± 0.50