2型糖尿病合并胃食管反流患者血清胃泌素水平分析.PDFVIP

 ·论 著· 2 型糖尿病合并胃食管反流患者 血清胃泌素水平分析 何素玉，刘益均，陈拥军，唐毅，徐建玉，吴艳 遂宁市中心医院消化内科（四川遂宁  629000） 【摘要】   目的    探讨 2 型糖尿病合并胃食管反流（gastroesophageal reflux disease，GERD）患者血清胃泌素水 平，分析其在 2 型糖尿病合并 GERD 患者中的可能作用。 方法    选取 2013 年 1 月—2015 年 1 月收治的 38 例 2 型 糖尿病合并 GERD 患者作为 A 组，40 例单纯 2 型糖尿病患者作为 B 组，36 例单纯 GERD 患者作为 C 组，40 名同 期医院体检中心的健康人员作为 D 组。对 4 组研究对象空腹血清胃泌素水平进行测定并对比分析。 结果    A 组 空腹血清胃泌素水平 [（116.53±22.02）pg/mL] 呈高分泌状态，较 B、C、D 组[（101.89±20.76）、（90.04±21.16）、 （92.48±19.69）pg/mL] 明显升高，差异有统计学意义（P0.01）；B 组较 C、D 组胃泌素水平升高，差异有统计学意 义（P0.05）；C、D 组胃泌素水平比较，差异无统计学意义（P0.05）。 结论     2 型糖尿病合并 GERD 患者血清胃 泌素呈高分泌状态。胃泌素分泌异常可能与 2 型糖尿病合并 GERD 的发生发展有着密切联系。 【关键词】  2 型糖尿病；胃食管反流；胃泌素 A study on the level of gastrin in patients with type 2 diabetes mellitus and gastroesophageal reflux disease HE Suyu, LIU Yijun, CHEN Yongjun, TANG Yi, XU Jianyu, WU Yan Department of Gastroenterology, Suining Central Hospital, Suining, Sichuan 629000, P. R. China Corresponding author: HE Suyu, Email: hesuyu2009@163.com 【Abstract】 Objective    To investigate the gastrin level in patients with type 2 diabetes mellitus (T2DM) with gastroesophageal reflux disease (GERD), and analyze the possible mechanism of gastrin in the pathogenesis of T2DM combined with GERD. Methods    Thirty-eight patients with T2DM combined with GERD treated between January 2013 and January 2015 were designated as group A; 40 patients with T2DM only were regarded as group B; 36 patients with GERD only were regarded as group C; and another 40 healthy volunteers who underwent physical examination at the same period were regarded as group D. The fasting serum levels of gastrin were measured and compared among the above four groups. Results    The fasting serum level of gastrin was significantly higher in group A [(116.53±22.02) pg/mL] than group B [(101.89±20.76) pg/mL], group C [(90.04±21.16) pg/mL], and group D [(92.48±19.69) pg/mL] (P0.01). The fasting serum level of gastrin in group B was significantly higher than group C and D (P0.05). There was no signifi