DiverseDisciplinesinChemistry.ppt

Diverse Disciplines in Chemistry;First: Who is Sitting Next to You?;Second: What’s the Plan Tonight?;What is Pharmacy?;What is Medicinal Chemistry?;Melding the Two Disciplines;Patient Case #1;Allergies: Sequence of Events;Indigestion: Sequence of Events;Are all Histamine Receptors the Same?;Chemists to the Rescue!;What does Histamine look like?;What is an “Antihistamine”?;1st Generation Antihistamines (H1);Structural Eval: Pharmacophore;Therapeutic Effects Observed;Where do Side Effects come from?;2nd Generation Antihistamines (H1);Any Structural Differences?;Does Patient Experience Change?;Back to Indigestion…;Structural Eval: Pharmacophore;Model: H2 Receptor Binding;H2 Receptors and Antagonists;Metabolism: Adverse Drug Reactions;Medicinal Chemistry Roles;Patient Case #2;Excretion: Drug-Food Interaction;Non-steroidal Anti-inflammatory Drugs;Structure Activity Relationships;Additional Patient Information;Absorption: Acid/Base Chemistry;Inflammation: Target for Drug Action;Therapeutic Effects Observed;Side Effect: GI upset;COX-2 Selective Inhibitors;Did we solve the problem?;Medicinal Chemistry + Pharmacy;Acknowledgements;THANK YOU!!