EffectofanAminoAcid.docVIP

Pediatric Asthma, Allergy Immunology Effect of an Amino Acid-based Milk—Neocate?—on Gastro-Oesophageal Reflux in Infants Assessed by Combined Intraluminal Impedance/pH To cite this article:Mike Thomson, Tobias G. Wenzl, Adam T. Fox, Raffaele Del Buono. Pediatric Asthma, Allergy Immunology. Winter 2006, 19(4): 205-213. doi:10.1089/pai.2006.19.205. Published in Volume: 19 Issue 4: December 28, 2006 Dr.?Mike?Thomson, M.D. Centre for Paediatric Gastroenterology, Royal Free and University College Medical School, London, NW3 2QG, UK. Tobias G.?Wenzl, Ph.D. Kinderklinik der RWTH Aachen, Aachen, Germany. Adam T.?Fox, M.Sc. Centre for Paediatric Gastroenterology, Royal Free and University College Medical School, London, NW3 2QG, UK. Raffaele Del?Buono, Ph.D. Centre for Paediatric Gastroenterology, Royal Free and University College Medical School, London, NW3 2QG, UK. Cows milk protein allergy-related gastro-oesophageal reflux (GOR) may be due to episodes of inappropriate lower oesophageal sphincter relaxation. The hypothetical physiological mechanism invoked to explain this involves a neurological consequence of the inflammatory infiltration induced from lamina propria vessels into the epithelial compartment. However, the efficacy of this approach has so examined with a physiologically-appropriate denominator to define the degree of GOR. We intend to conduct an investigation of the influence of Neocate? an amino acid-based milk, on GOR in infants by using a combined pH and intraluminal oesophageal impedance measurement. 11 infants (6 male, median age 151 days, range 75 to 345 days) bottle-fed with either expressed breast milk or formula milk, with symptoms clinically suggestive of GOR, underwent two 24-hour studies of intra-oesophageal 6 channel impedance and dual-channel pH monitoring before and 14 days after establishment on Neocate? amino acid formula. Impedance/ pH reflux data were recorded and analysed blind by one observer. Ten out of 11 infants parents repo