RapidInformationonOLMNo7.docVIP

PAGE  PAGE 6 Rapid Information on Olmesartan and other ARBs No.224 2014/07/21 　　　　　　　　　　　　　　　　　 　　　　　　　　　Be the first to know! 　　　 　 　　 (Toru Komai, Ph.D.) 224-1: Olmesartan is effective and well tolerated in all patients, irrespective of their socio-economic status. Title：Impact of socio-economic factors on the long-term effectiveness of antihypertensive treatment with an angiotensin II receptor blocker: An observational study. 2-3 224-2: Among different ARBs and CCBs, olmesartan uniquely increases urinary ACE2 level. The finding suggests that olmesartan induces ACE2 expression in the kidney, affording renoprotection by its pleiotropic effects. Title：Urinary Angiotensin-Converting Enzyme 2 in Hypertensive Patients May Be Increased by Olmesartan, an Angiotensin II Receptor Blocker. 3-4 224-3: There were no differences in the cardiovascular risk reduction conferred using olmesartan in combination with either a CCB or a diuretic. The incidence of serious adverse events, however, was significantly lower in the olmesartan plus CCB group than in the olmesartan plus diuretic group. (COLM study) Title：Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial1. 5-6 Abbreviations: BP: blood pressure, SBP/DBP: systolic/ diastolic BP, RAS: renin–angiotensin system, Ang II: angiotensin II, ARB: angiotensin II receptor blocker, CCB: calcium channel blocker, ACE-I: angiotensin converting enzyme inhibitor, OLM: olmesartan, AML: amlodipine, HCTZ: hydrochlorothiazide, HR: hazard ratio, OR: odds ratio, 224-1: Olmesartan is effective and well tolerated in all patients, irrespective of their socio-economic status. Socio-economic status (SES) has been shown to be inversely related to mortality from hypertension-related disorders such as stroke, coronary heart disease,