RapidInformationonOLMNo9.docVIP

PAGE  PAGE 6 Rapid Information on Olmesartan and other ARBs No.223 2014/07/09 　　　　　　　　　　　　　　　　　 　　　　　　　　　Be the first to know! 　　　 　 　　 (Toru Komai, Ph.D.) 223-1: Olmesartan ameliorated hypertension-related erectile dysfunction in the SHR through the improvement of the blood pressure and NO synthase activity, and on the other hand by decreasing the oxidative stress levels. Title：Effect of an angiotensin II receptor blocker and a calcium channel blocker on hypertension associated penile dysfunction in a rat model. 2-3 223-2: Treatment with olmesartan ameliorated tacrolimus-induced nephrotoxicity in rat, implying that RAS might be playing a role in tacrolimus-induced nephrotoxicity. Title：Olmesartan attenuates tacrolimus-induced biochemical and ultrastructural changes in rat kidney tissue. 3-4 223-3: The BP lowering effect of olmesartan in KKAy mice is associated with an improvement in adipocyte, including suppression of adipocyte hypertrophy and inhibition of the adipose IL-6-oxidative stress axis. Title：Effects of the Angiotensin receptor blocker olmesartan on adipocyte hypertrophy and function in mice with metabolic disorders. 5 Abbreviations: BP: blood pressure, SBP/DBP: systolic/ diastolic BP, RAS: renin–angiotensin system, Ang II: angiotensin II, ARB: angiotensin II receptor blocker, CCB: calcium channel blocker, ACE-I: angiotensin converting enzyme inhibitor, OLM: olmesartan, 223-1: Olmesartan ameliorated hypertension-related erectile dysfunction in the SHR through the improvement of the blood pressure and NO synthase activity, and on the other hand by decreasing the oxidative stress levels. Hypertension represents one of the major risk factors for the development of vasculogenic erectile dysfunction (ED). Clinical studies show that approximately 30% of hyper