1-s2.0-S1936879810000294-main.pdf

CT C A A M L O n c B I l t M c b 6 a R o 2 p 0 c s v C r b F ? M J A C C : C A R D I O V A S C U L A R I N T E R V E N T I O N S V O L . 3 , N O . 3 , 2 0 1 0 ? 2 0 1 0 B Y T H E A M E R I C A N C O L L E G E O F C A R D I O L O G Y F O U N D A T I O N I S S N 1 9 3 6 - 8 7 9 8 / 1 0 / $ 3 6 . 0 0 P U B L I S H E D B Y E L S E V I E R I N C . D O I : 1 0 . 1 0 1 6 / j . j c i n . 2 0 0 9 . 1 2 . 0 1 1LINICAL RESEARCH he Impact of Transcatheter Atrial Septal Defect losure in the Older Population Prospective Study rif Anis Khan, MD,* Ju-Le Tan, MD,*? W. Li, PHD,* Kostas Dimopoulos, MD, PHD,* ark S. Spence, MD,*? Pak Chow, MD,*§ Michael J. Mullen, MD* ondon, United Kingdom; Mistri Wing, Singapore; Belfast, Ireland; and Hong Kong, China bjectives We sought to prove that device closure of atrial septal defect (ASD) in older patients ot only improves cardiac function but also results in symptomatic relief by improving functional lass. ackground Atrial septal defect accounts for approximately 10% of all congenital cardiac defects. t is possible that ASD closure in older patients may derive benefits, though this is not well estab- ished. We therefore aim to prospectively assess the clinical status and functional class of older pa- ients after transcatheter ASD closure. ethods This was a prospective study of all patients age 40 years or more who underwent device losure of a secundum ASD between April 2004 and August 2006. Investigations including atrial and rain natriuretic peptide levels, electrocardiography, chest X-ray, transthoracic echocardiogram, -min walk test, and quality of life questionnaire were performed before and at 6 weeks and 1 year fter the procedure. esults Twenty-three patients (median age 70 years, 13 women) had transcatheter device closure f ASD. Median ASD size was 18 mm (range 9 to 30 mm). Median pulmonary artery pressure was 2 mm Hg (range 12 to 27 mm Hg). At 1 year, New York Heart Association functional class im- roved (p
0.004) in 16 patients with