Acute Administration of Zn, Mg.pdf

Archives of Iranian Medicine, Volume 15, Number 5, May 2012306 Original Article Abstract Background: Postpartum depression (PPD) affects approximately half of new mothers. Chronic exposure to progesterone during preg- nancy and its withdrawal following delivery increases depression and anxiety. In addition, there are complex interactions between hormones, - sion in the brain. Thiamine (Vit B1 in pregnancy are implicated in the pathogenesis of major depression. Methods: We examined the effects of different combinations of Zn, Mg, and Vit B1 in an animal model of PPD. ZnCl, MgCl, and thiamine- HCl were administered to PPD-induced mice. Depression, anxiety-related behavior, and total antioxidant capacity (TAC) were assessed. Depression and anxiety-like behavior were evaluated by the forced swimming test (FST) and elevated plus-maze, respectively. Results: The acute combined administration of Zn, Mg, and Vit B1 of both time spent in- and entries to open arms in the elevated plus-maze, and augmented TAC. Conclusion: Our data suggest that acute administration of combined treatment with Zn, Mg, and Vit B1 on postpartum day 3 improves depressive symptoms and anxiety-like behaviors. Our evaluation of TAC is in accordance with behavioral results. Keywords: Anxiety, depression, magnesium, thiamine, Zinc Cite this article as: Nikseresht S, Etebary S, Karimian M, Nabavizadeh F, Zarrindast MR, Sadeghipour HR. Acute Administration of Zn, Mg, and Thiamine Improves Postpartum Depression Conditions in Mice. Arch Iran Med. 2012; 306 – 311. Introduction A depressed mood is common during the postpartum period, following delivery. This transient mood disturbance in vul- nerable women may lead to more serious and persistent depression for major depression, known as postpartum depression (PPD).1,2 Evidence suggests that maternal depression is harmful for new mothers, their infants, and family relationships. PPD can also im- pair the infant’s cognitive and social development. T