Proteintargeting靶向蛋白选编.doc

Protein targeting From Wikipedia, the free encyclopedia This article deals with protein targeting in? HYPERLINK /wiki/Eukaryote \o Eukaryote eukaryotes?except where noted. Protein targeting?or?protein sorting?is the biological mechanism by which? HYPERLINK /wiki/Protein \o Protein proteins?are transported to the appropriate destinations in the cell or outside of it. Proteins can be targeted to the inner space of an? HYPERLINK /wiki/Organelle \o Organelle organelle, different intracellular? HYPERLINK /wiki/Biological_membrane \o Biological membrane membranes,? HYPERLINK /wiki/Cell_membrane \o Cell membrane plasma membrane, or to exterior of the cell via  HYPERLINK /wiki/Secretion \o Secretion secretion. This delivery process is carried out based on information contained in the protein itself. Correct sorting is crucial for the cell; errors can lead to diseases. 靶向蛋白 维基百科，自由的百科全书 这篇文章除了注意的地方在真核生物蛋白靶向交易。 蛋白靶向或蛋白质排序是通过该蛋白质运输到细胞中的相应的目的地或它的外部的生物机制。蛋白质可靶向至细胞器，不同细胞内膜，质膜的内部空间，或通过分泌细胞的外部。这个输送过程是基于包含在该蛋白质本身的信息进行的。正确的排序是细胞的关键;错误可以导致疾病的发生。 Targeting signals Targeting signals are the pieces of information that enable the cellular transport machinery to correctly position a protein inside or outside the cell. This information is contained in the? HYPERLINK /wiki/Primary_structure \o Primary structure polypeptide chain?or in the folded protein. The continuous stretch of? HYPERLINK /wiki/Amino_acid \o Amino acid amino acid?residues in the chain that enables targeting are called? HYPERLINK /wiki/Signal_peptide \o Signal peptide signal peptides?or? HYPERLINK /wiki/Targeting_peptide \o Targeting peptide targeting peptides. There are two types of targeting peptides, the presequences and the internal targeting peptides. The presequences of the targeting peptide are often found at the N-terminal extension and is composed of between 6-136 basic and hydrophobic amino acids. In case of peroxisomes the targeting sequence is on the C-terminal extension mostly. Oth