PCT、IL-6对脓毒症早期诊断价值的meta分析.doc

PCT、IL-6对脓毒症早期诊断价值的meta分析 【摘要】目的：探讨PCT、IL-6对脓毒症早期的临床诊断价值。方法：根据关键词检索文献后，按照纳入标准和排除标准进行文献筛选，利用R2.15.1软件对收集到的文献数据进行Meta分析。采用异质性检验方法，计算各生物标志物检验脓毒症的敏感度和特异度。结果：根据有哪些信誉好的足球投注网站策略检索到480篇相关文献，筛选后有22篇文献入选，其中包括中文文献13篇，英文文献9篇，异质性检验结果显示各组文献间差异具有统计学意义（χ2值=33.25，P0.05），对文献的meta分析结果表明：PCT和IL-6是最具有检测价值的生物标记物，其中，PCT对脓毒症诊断的敏感度和特异度分别为84.1%和80.2%，而IL-6的相应数据分别为80.2%和77.4%。结论：降钙素原对脓毒症的早期诊断具有较高的临床价值，同时配合IL-6诊断，能够进一步提高对脓毒症早期诊断的敏感度和特异度。 【关键词】脓毒症，PCT，IL-6，敏感度，特异度 Analysis of PCT, IL-6 in early diagnosis of sepsis in meta Abstract: Objective: To investigate the clinical diagnostic value of PCT, IL-6 in sepsis early. Methods: according to the keywords retrieval literature, in accordance with the inclusion criteria and exclusion criteria for literature screening, Data collected by the R2.15.1 software of Meta analysis. The heterogeneity test method to calculate the biomarker test sepsis sensitivity and specificity. Results: according to the search strategy of 480 relevant literatures were collected, 22 papers were selected, including 13 Chinese papers, 9 English literatures, heterogeneity test results showed statistically significant differences between the groups of literature (χ 2 =33.25, P0.05), meta analysis of the literature suggests that PCT and IL-6 are biological markers, most has the value of detection of PCT among them, were 84.1% and 80.2% for sepsis diagnostic sensitivity and specificity, and IL-6 on sepsis diagnostic sensitivity and specificity were 80.2% and 77.4%. Conclusion: Calcitonin has higher clinical value in the early diagnosis of sepsis, With the IL-6 diagnosis, can further improve the early diagnosis of sepsis sensitivity and specificity. Keywords: sepsis, PCT, IL-6, sensitivity, specificity 脓毒症是由感染引起的全身炎症反应综合症（常见的类型包括腹腔感染、严重的肺部感染、皮肤感染、泌尿系统感染和??内感染等[1]），患者可能存在高度可疑的感染病灶，临床证实有病原微生物（例如病毒、细菌、真菌和寄生虫等）[2]。当脓毒症患者器官功能不全时会形成重度脓毒症，而重度脓毒症患者同时合并低血压时，可能引起脓毒性休克，严重威胁患者生命健康[3-4]，因此，对脓毒症患者进行及时的诊断和合理的治疗具有重要的临床意义。 目前对脓毒症诊断标准的主要依据为患者的临床症状和体征，这种诊断方法不具有明显的特异性。而对患者血液的细菌培养耗时较长（至少需要48小时），并且诊断的准确率较低（超过40%的细菌培