CXCR7在常见皮肤恶性肿瘤及其细胞株中的表达及意义.pdfVIP

????????????????!l??12??????????12????h??????????Q!??Q????????1??，??丝，Ⅸ?? -?????? CXCR7?????????????????????? 细胞株中的表达及意义 李小静刘排 陈浩刘毅程芳张磊周武庆蒋明军孙建方 【摘要】 ????????????????????CXCR7?????????????????????????????????????????????????? 细胞株中的表达及其意义。方法收集?例皮肤鳞状细胞癌、?例基底细胞癌、?例皮肤黑素瘤的癌组 织，??用免疫组织化学方法，检测???鞍妆泶锼?健２捎肦???⑾赴?庖咦榛?椒?觳釩??在 A375??M14??A431??HaCaT????????mRNA????????????????CXCR7?????????????????????????????? ??????????80??(24??30)??????????????????????????????????26??67??(8??30)??8??(2??25)???????????? ???弑泶锫视肓圩聪赴??⒒?紫赴?┍冉希?钜炀?型臣蒲б庖??捣直鹞????????琍值 均?．? ??? ??在??、?????赴?曛芯?杉斐觯?渲蠥??泶镒钋浚?鳫??细胞不 表达；细胞免疫组化显示，仅在??细胞见棕黄色颗粒着色。结论皮肤黑素瘤及其细胞株??高表达 CXCR7???????????????????????????????? 【关键词】黑色素瘤；癌，鳞状细胞；癌，基底细胞；受体，趋化因子；细胞系，肿瘤 ????? and ?????? ? CXCR7 chemokine ???? ? cutaneous malignant ??? and their ?? lines ??2??????? ??珻????? Yi??CHENG????? Lei??ZHOU?—??鐹?? Ming-jun??SUNJian-fang??Institute? Dermatology,Chinese Academy ? Medical ???? and ??? Union Medical ?Ⅱ??甆??? 210042??China Corresponding authof??SUNJian-fang,Email??fangmin5758C??ahoo??corn??cn ??Abstract??0bjective? investigate the ????? ? CXCR7 ? several cutaneous malignant ??? including cutaneous ???? ?? carcinoma(SCC)??basal?? carcinoma(BCC)and ???? cutaneous malignant ????