天然药物化学史话奎宁的发现、化学结构以及全合成.PDFVIP

中草药 Chinese Traditional and Herbal Drugs 第 45 卷 第 19 期 2014 年 10 月 ·2737· ·专 论· 天然药物化学史话：奎宁的发现、化学结构以及全合成 郭瑞霞 1, 2，李力更 2，付 炎 2，霍长虹 2，王 磊 2，史清文 2* 1. 石家庄学院化工学院 药物化学教研室，河北 石家庄 050017 2. 河北医科大学药学院 天然药物化学教研室，河北 石家庄 050017 摘 要：奎宁是非常著名的天然药物，曾经挽救了无数人的生命，甚至被认为影响了人类的发展进程，对奎宁的研究也在科 学史上留下了非常重要的记录。着重对奎宁的发现、结构鉴定、生物活性和全合成做了简要介绍，以纪念在奎宁的研究中做 出伟大贡献的科学家，同时为科研人员在复杂天然产物全合成工作中开阔眼界提供一些思路。 关键词：奎宁；天然药物；全合成；抗疟；金鸡纳 中图分类号：R284 文献标志码：A 文章编号：0253 - 2670(2014)19 - 2737 - 05 DOI: 10.7501/j.issn.0253-2670.2014.19.001 Historical story on natural medicinal chemistry: Isolation, structure, and total synthesis of quinine GUO Rui-xia1, 2, LI Li-geng2, FU Yan2, HUO Chang-hong2, WANG Lei2, SHI Qing-wen2 1. Department of Pharmacochemistry, College of Chemical Engineering, Shijiazhuang College, Shijiazhuang 050017, China 2. Department of Nature Pharmacochemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China Abstract: Quinine is a very famous natural medicine that has saved millions of lives, even being believed to affect the development process of human beings. The study of quinine has left a very important record in the history of science. In this paper, the historical stories on the discovery and study of quinine are summarized in memory of the great discoveries and in honor of the scientists. It also aims at providing the references for future related research. This article is one of the series of historical stories on natural product chemistry written by the authors. Key words: quinine; natural medicine; total synthesis; antimalarial; Cinchona ledgeriana (Howard) Moens ex Trim. 奎宁（quinine）是非常著名的天然药物，曾经 是奎宁的全合成被认为是开创了立体选择性反应 挽救了无数人的生命，甚至被认为影响了人类的发