中山市体检人群非酒精性脂肪肝危险因素的病例对照研究.doc

非酒精性脂肪肝危险因素的病例对照研究 钟淑婷1 李燕青2 将卓勤3 王林静4 (1.广州医学院第三附属医院临床营养科,广州，510150;2.中山市博爱医院营养室，中山，528403;3.中山大学公共卫生学院营养系教授，广州，510080;4.广东药学院预防医学系副教授，通信员，广州，510310) 摘要：[目的] 探讨中山市体检人群非酒精性脂肪肝(NAFLD)的危险因素。[方法] 将经B超确诊的非酒精性脂肪肝患者按年龄、性别作1:1配对进行病例对照研究，共306对。[结果] 单因素分析结果显示超重及肥胖、血糖代谢紊乱、高血压、血脂异常、高尿酸血症、胆囊结石、喜食甜食、喜食零食、经常睡前加餐、常食肉类、常食煎炸食物、常食蔬菜、常食水果、经常饮茶、经常运动与NAFLD关系密切；多因素分析结果显示超重及肥胖、血糖代谢紊乱、高血压、血脂异常是NAFLD的危险因素，常食蔬菜、常食水果、经常饮茶、经常运动是NAFLD的保护因素???[结论] 积极治疗、控制原发病，加强对饮食结构及生活方式的干预是有效防治非酒精性脂肪肝的关键。 关键词:非酒精性脂肪肝，危险因素，病例对照研究 ABSTRACT：[Objective] explore risk factors of nonalcoholic fatty liver of health examination people in ZhongShan. [Methods] 306 cases of NAFLD and 306 controls who are diagnosed by B-ultrasonic examination are conducted by a 1:1 matched case-control study. [Results] It shows NAFLD has a close relationship with overweight or obesity, blood glucose metabolic disorders, hypertension, abnormal blood lipids, hyperuricemia, gallstone disease, fond of eating sweet food, fond of eating snacks, extra-meal before sleep, frequently eating meat, frequently eating fried food, frequently eating vegetables, frequently eating fruits, frequently drinking tea, and doing more exercise by using single-factor analysis. Multi-factor analysis indicates that the following factors: overweight or obesity, blood glucose metabolic disorders, hypertension, and abnormal blood lipids are the risk factors of NAFLD. Frequently eating vegetables, frequently eating fruits, frequently drinking tea, and doing more exercise are the protective factors of NAFLD. [Conclusion] Treating actively and controling protopathy, strengthening the intervention on diet structure and life styleare the key points to prevent fatty liver. Key words: nonalcoholic fatty liver, risk factor, case-control study 近年来，随着生活水平的提高，生活方式和饮食习惯的改变，非酒精性脂肪肝(NAFLD)的患病率不断上升，且发病年龄年轻化，已成为全球性的公共卫生问题。多数NAFLD呈良性、慢性过程，临床上最常见单纯性脂肪肝和脂肪性肝炎，但少数可发展为肝纤维化和肝硬化，甚至发生终末期的肝功能衰竭、肝癌，严重威胁着人类的健康。本论文以中山市某综合性医院的体检人群为研究对象，通过问卷调查、体格检查、生化检查、B超检查等测量手段，来探讨中山市体检人群非酒精性脂肪肝的危险因素，为中山市开展NAF