亚低温与神经干细胞移植干预缺血缺氧性脑病叠加的神经保护作用.doc

SICENCE新闻发布 作者：王林 稿号：NRR_311_14 亚低温与神经干细胞移植干预缺血缺氧性脑病：叠加的神经保护作用 神经干细胞移植可用于治疗缺血性脑卒中，但移植后的神经干细胞在缺血缺氧大脑微环境中常出现凋亡，而亚低温疗法具有强大的神经保护作用，来自中国上海交通大学的王林所在团队构想了以亚低温（27–28 °C）联合神经干细胞移植（1.0×105 /μL）共同干预缺血缺氧性脑病，会得到更好的神经保护作用的设计。在实验中发现亚低温联合神经干细胞移植效果优于单独应用亚低温或神经干细胞移植治疗的效果，其作用可能通过抗炎和抗凋亡的多重途径来实现。文章发表在《中国神经再生研究（英文版）》杂志2014年10月第19期。 Article: Mild hypothermia combined with neural stem cell transplantation for hypoxic-ischemic encephalopathy: neuroprotective effects of combined therapy, by Lin Wang, Feng Jiang, Qifeng Li, Xiaoguang He, Jie Ma (Department of Pediatric Neurosurgery, Xinhua Hospital of Shanghai Jiaotong University, Shanghai 200092, China) Wang L, Jiang F, Li QF, He XG, Ma J. Mild hypothermia combined with neural stem cell transplantation for hypoxic-ischemic encephalopathy: neuroprotective effects of combined therapy. Neural Regen Res. 2014;9(19):1745-1752. 欲获更多资讯： HYPERLINK /Neural Regen Res Mild hypothermia and NSCs transplantation protect against hypoxic-ischemic encephalopathy Neural stem cells (NSCs) transplantation is a useful treatment for ischemic stroke, but apoptosis often occurs in the hypoxic-ischemic environment of the brain after cell transplantation. Wang Lin and his colleagues, Shanghai Jiaotong University, China, hypothesized that mild hypothermia (27–28 °C) combined with NSCs (1.0×105 /μL) transplantation exhibit better neuroprotective effects on hypoxic-ischemic encephalopathy than monotherapy. Their experimental results confirm that mild hypothermia combined with NSCs transplantation is superior to monotherapy in the treatment of hypoxic-ischemic encephalopathy, and the neuroprotective effects are achieved through anti-inflammatory and anti-apoptotic mechanisms. The relevant study has been published in Neural Regeneration Research (Vol. 9, No. 19, 2014). Article: Mild hypothermia combined with neural stem cell transplantation for hypoxic-ischemic encephalopathy: neuroprotective effects of combin