量子点荧光探针在定量分析中的应用_梁佳然.pdf

第 20 卷 第 9 期 化 　学 　进 　展 Vol .20 No .9 2008 年 9 月 PROGRESS IN CHEMISTRY 　Sep ., 2008 量子点荧光探针在定量分析中的应用＊ 梁佳然1 　钟文英1 ＊＊ 　于俊生2 (1 .中国药科大学基础部分析化学教研室 　南京 210009 ;2 .南京大学化学化工学院 　南京 210093) 摘 　要 　量子点是半径小于或接近于激子玻尔半径的一类半导体纳米晶 , 作为一种新型的荧光标记物 , 其独特和可调谐的光学特性(宽的激发光谱 、窄的发射光谱 、可精确调谐的发射波长以及可忽略的光漂白等) 使其在生物和医学方面显示出巨大的应用潜力 。 近年来量子点在定量分析方面的应用也取得了很大进展 , 为分析化学的含量测定提供了一种新的方法和技术 , 显示出极大的优越性 。 本文就量子点在金属离子和药 物等的含量测定方面国内外的研究进展进行了综述 。 关键词 　量子点 　定量分析 　金属离子 　药物 中图分类号 :O657 .39 ;O611 .4 　文献标识码 :A 　文章编号 :1005-281X(2008)09-1385-06 Application of Quantum Dots(QDs)as Fluoresent Probes in Quantitative Analysis Liang Jiaran1 　Zhong Wenying1 ＊＊ 　Yu J unsheng2 (1 .Department of Analytical Chemistry , China Pharmaceutical University , Nanjing 210009 , China ; 2 .School of Chemistry and Chemical Engineering , Nanjing University , Nanjing 210093 , China) Abstract 　Quantum dots (QDs)are a kind of semiconductor nanopaticles with the radius equal to or less than the exciton Bohr radius .They have tremendous potential in the field of biology and medicine because of their unique and tunable optical properties (broad excitation spectrum , narrow emission spectrum , precise tunability of their emission peak and negligible bleaching , etc)as new fluoresent probes .Recently , because of their superiority in sensitivity , a new method based on them is introduced to analysis , and made great progress in the quantitative analysis .Here the applications of QDs in the assay of metal ions , some drugs and compounds , as well as the current research progress are reviewed according to the advanced works world