银促进的α-氨基芳乙酮与NH4PF6的缩合环化反应：2-芳甲酰基咪唑衍生物的合成研究.pdf

Journal of Organic Chemistry Research 有机化学研究, 2016, 4(1), 6-12 Published Online March 2016 in Hans. /journal/jocr /10.12677/jocr.2016.41002 Silver-Promoted Cyclization of α-Aminoacetophenone with NH4PF6: Synthesis of 2-Arylformylimidazole Derivatives Zuohui Wang, Xiaoxue Cheng, Hao Wang, Xinru Ling, Chenchen Zhao, Maolin Hu* College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou Zhejiang Received: Feb. 15th, 2016; accepted: Mar. 7th, 2016; published: Mar. 10th, 2016 Copyright ? 2016 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract A new method for AgOAc-oxidative cyclization of α-aminoacetophenones with NH4PF6 leading to 2-arylformylimidazoles derivatives has been developed. Under the optimal reaction conditions, a wide range of 2-arylformylimidazoles derivatives were synthesized in moderate to good yields ranging from 52% to 93%. These products were confirmed by IR, NMR and MS. The results show that this method has advantages such as the availability for raw materials and simple chemical operations. Keywords α-Aminoacetophenone, Imidazole, Condensation, Cyclization, Oxidative Deamination 银促进的α-氨基芳乙酮与NH4PF6的缩合环化反 应：2-芳甲酰基咪唑衍生物的合成研究 王祚辉，程晓雪，王 浩，凌心茹，赵晨晨，胡茂林* 温州大学化学与材料工程学院，浙江 温州 *通讯作者。