锐孔法制备壳聚糖-姜黄素微囊.pdf

第 39 卷第 2 期 唐山师范学院学报 2017年 3 月 Vol.39 No.2 Journal of Tangshan Normal University Mar. 2017 化学与化工 锐孔法制备壳聚糖-姜黄素微囊 刘 欣，郎凯凯，仇 娟，贺慧慧，马 周 （唐山师范学院 化学系，河北 唐山 063000） 摘 要：用锐孔法以壳聚糖为囊材制备了姜黄素微囊。采用单因素变量法探讨了壳聚糖浓度、NaOH 浓度、 姜黄素浓度、转速、温度、针头孔径、下滴高度等因素对微囊包封率的影响。通过正交试验确定了最佳制备工 艺条件为壳聚糖质量分数为 6.0%、氢氧化钠浓度 4.0 mol·L-1、姜黄素质量分数为 2.0%、针头孔径 0.6 mm、下 滴高度 10 cm、温度 20 ℃ 、转速 450 r·min-1。制得的微囊为橙红色球状颗粒，大小均匀，包封率为 60%，载药 量达到 0.75%。姜黄素微囊化后稳定性明显增强。 关键词：壳聚糖；姜黄素；微囊；锐孔法 中图分类号：R944.5 文献标识码：A 文章编号：1009-9115(2017)02-0015-05 DOI：10.3969/j.issn.1009-9115.2017.02.005 Preparation of Curcumin Micro-Capsules with Chitosan as Encapsulating Material by Piercing Method LIU Xin, LANG Kai-kai, QIU Juan, HE Hui-hui, MA Zhou (Department of Chemistry, Tangshan Normal University, Tangshan 063000, China) Abstract: Curcumin microcapsules were prepared with chitosan as encapsulating material by piercing method. The impact of the concentration of chitosan, the concentration of sodium hydroxide, the concentration of curcumin, stirring speed, curing temperature, needle aperture, drop height on the encapsulation efficiency were studied by the single factor experiment. The optimum conditions were determined by orthogonal experiment and the results showed that the concentration of chitosan was 6.0%, the concentration of sodium hydroxide was 4.0 mol·L-1, the concentration of curcumin was 2.0%, the stirring speed was 450 r·min-1, the curi