我院门诊输液区137例患儿静脉滴注给药致不良反应报告分析.pdf

我院门诊输液区137例患儿静脉滴注给药致不良反应报告分析 何 珊＊，常 宏#，赵雅妮（南方医科大学附属深圳市妇幼保健院，广东 深圳 518028） 中图分类号 R969.3 文献标志码 A 文章编号 1001-0408（2015）17-2359-03 DOI 10.6039/j.issn.1001-0408.2015.17.19 摘 要 目的：了解我院门诊输液区患儿静脉滴注给药致药品不良反应（ADR）发生的规律及特点，为临床合理运用静脉滴注治疗 提供参考。方法：收集我院 2013 年 12 月－2014 年 11 月门诊输液区发生并上报的 137 例儿童静脉滴注给药致 ADR 报告并进行统 计、分析。结果：137例ADR报告中，原患疾病全部为感染性疾病；男性、女性患儿报告数差异无统计学意义（P＝0.073）；4～6岁组 报告的例数最多（占 45.99％）；ADR 多发于 1 d 内的后 12 个 h；春季是儿童 ADR 的高发季节（占 45.25％）；抗菌药物引起的 ADR 发 生率最高（占 75.50％）；患儿 ADR 以皮肤及其附件最常见（占 90.51％）；有 22 例新的一般的 ADR 报告。结论：临床在给予患儿静 脉滴注用药时，应充分考虑其与成人的差异产生的药物作用的独特性，并跟踪患儿用药反应，切实减少ADR的发生。 关键词 药品不良反应；儿童；合理用药；静脉滴注 Analysis of 137 Cases of Pediatric Adverse Drug Reaction by Intravenous Infusion in Transfusion Area of Out- patient Department in Our Hospital HE Shan，CHANG Hong，ZHAO Ya-ni（The Affiliated Shenzhen Maternity and Child Healthcare Hospital，South- ern Medical University，Guangdong Shenzhen 518028，China） ABSTRACT OBJECTIVE：To study the regularity and the characteristics of pediatric ADR by intravenous infusion in transfu- sion area of outpatient department in our hospital，promote the rational drug use and improve the awareness of medical staff about the pediatric ADR monitoring. METHODS：137 cases of pediatric ADR reported in transfusion area of outpatient depart- ment from Dec. 2013 to Nov. 2014 were collected and statistically analyzed. RESULTS：Among the 137 cases，the primary dis- ease was infectious disease；male case was more than female（P＝0.073），children aged 4-6 years old occupied the highest pro- portion（45.99％），ADR mainly occurred in the last 12 h in a day and ADR cases occupied the highest proportion in spring （45.25％）；ADR cases caused by antibiotics stood the highest（75.50％）；the main clinical manifestations of ADR cases were the lesions of skin