IL-21scFv.pptVIP

The research of human single chain Fv antibody against IL-21 ;Research Purpase;Research Significance; Biological activity of IL-21;; The data from experimental models of immunity suggest that inhibiting IL-21 actions could be useful for the treatment of several inflammatory and autoimmune diseases.;; At present, we can find many references on IL-21, but the study on antibodies against IL-21 is still seldom. Some approaches for inhibiting IL-21 activity have not reached the clinic. ; The anti-IL-21 scFv we obtained are fully human in nature, which reduces the potential for an adverse immunological effect, and it can be produced very efficiently by using bacterial protein synthesis systems and this is beneficial for reducing time and cost.; Furthermore, the binding domain of the anti-IL-21 scFv can be characterized with respect to affinity and biological activity. They can be engineered into multivalent, bi-specific and conjugated forms by fusing to another functional regents, such as toxin, cytokines or another antibody.