每日摄取葡萄皮提取物花青素后对大鼠血清抗氧化能力的影响.pdf

Physiol. Res. 60: 637-645, 2011 Effect of the Daily Ingestion of a Purified Anthocyanin Extract From Grape Skin on Rat Serum Antioxidant Capacity M. G. LIONETTO1, M. E. GIORDANO1, A. CALISI1, E. ERROI1, F. DE NUCCIO1, T. SCHETTINO1 1Department of Biological and Environmental Sciences and Technologies, University of Salento, Italy Received July 24, 2010 Accepted December 10, 2010 On-line May 16, 2011 Summary Introduction The aim of this work was to study the effect of the daily ingestion of a purified anthocyanin extract from red grape skin on Anthocyanins are chemically phenolic rat serum antioxidant capacity (ORAC) and its safety for the compounds belonging to the flavonoid family responsible intestinal epithelium. The study was carried out in rats orally for the colours of flowers and fruits of a great variety of administered with the extract for 10 days in either normal plants. They have been shown to possess beneficial in physiological conditions or exposed to a pro-oxidant chemical vitro properties related to the protection against (CCl4). The oral administration of the extract significantly pathologies involving oxidative stress, such as (P0.05) enhanced the ORAC value of the deproteinised serum cardiovascular diseases, cancer, neurodegeneration, of about 50 % after 10 days of ingestion. Anthocyanin inflammation, and viral infection (Prior and Wu 2006). In administration was also able to reverse completely the decrease particular, anthocyanins are potent antioxidants (Khkonen in the serum ORAC activity induced by the CCl4 treatment. and Heinonen 2003) because of their ability to quickly Experiments with Ussing chamber mounted intestine allowed to reduce oxidizing species while being converted into exclude any toxicity of the extract for the intestinal epithelium. In stabilized aryloxyl radicals. Moreover, they are able to conclusion, our results demonstrate that the purified a