p3疼痛基础研究方法.ppt

疼痛的动物模型与研究方法Animal Models and MethodsIn Pain Research ;常用的动物模型;常用的动物模型;常用的动物模型;常用的动物模型;Animal models of pain;Animal models of pain;扭体模型;The Abdominal Constriction (Writhing) Test;白陶土-鹿角菜胶炎症模型;福尔马林致痛模型;福尔马林致痛模型;慢性病理性疼痛;炎症痛模型 inflammatory pain model;Ankle joint: intra-articular injection of CFA;0;Animal models of pain;Neuropathic pain from nerve inflammation;L2;Date;Allodynia in rats infected with varicella zoster virus—a small animalmodel for post-herpetic neuralgia;Fig. 1. Duration of VZV-induced allodynia;Fig. 2. Reproducibility of the model;Fig. 3. Specificity of the model;Animal models of pain;Chemotherapy-evoked painful peripheral neuropathy (1);Chemotherapy-evoked painful peripheral neuropathy (2);Colonic-Rectal Distension;Animal models of pain;癌痛实验进展情况;小鼠脚掌皮肤癌痛模型;小鼠脚掌肿瘤生长情况;疼痛的常见症状;慢性痛的常见症状;痛敏的种类与机制;⊙;Philosophy of Measuring Pain;Philosophy of Measuring Pain;Philosophy of Measuring Pain;Measuring pain in animals;Methods in Pain Research;单通道电流的记录 Neher Sakmann (1976, 1981) 微玻管 去神经肌膜 1991 获诺贝尔奖;影响伤害性感受测量的因素;Strain and sex differences in basal threshold in mice;测量疼痛的两类方法;常用的痛刺激方法;实验动物的疼痛评价方法;实验动物的疼痛评价方法;动物疼痛的行为学研究方法;外周神经损伤后的机械痛敏;;辐射热甩尾测定痛阈（电针）;Date;Date;Date;0;Date;Date;Date;Date;Date;The Abdominal Constriction (Writhing) Test;Date;Date;疼痛的研究方法;脊髓丘脑束神经元中枢敏化;Date;Vanilloid receptor type 1 (VR1) Distributionin DRG in Normal Rats;Change of VR1 Expression in DRG after CFA Injection;Correlation between Hyperalgesia and VR1 Protein Level ;PAIN;Three different typical patterns of ectopic discharges;Changes of ectopic discharges after SNL;Correlation analysis between tactile allodynia and ectopic activity in the first 24 hours after SNL;Correlation analysis between tactile allodynia and ectopic activity in the days 1-14 after SNL;Neuropathic pain:Early spontaneous afferent activity is the trigger;Allodynia;Wind-up of a WDR neuron;Induction of LTP of C-fiber-evoked potentials in the spinal dorsal horn in sham-operated and neuropathic pain rats ;单通道电流的记录 Neher