Ezrin蛋白及其磷酸化水平在皮肤鳞癌基底细胞癌脂溢性角化中的表达及其临床意.doc

Ezrin蛋白及其磷酸化水平在皮肤鳞癌、基底细胞癌、脂溢性角化中的表达及其临床意义 伍斌1，谢红付2，张江林2，李吉2 湘南学院附属医院皮肤科，湖南郴州423000；2.中南大学湘雅医院皮肤科，湖南长沙410008） 摘要：目的探讨Ezrin蛋白及磷酸化Ezrin（phos-Ezrin）在SK、BCC、SCC中的表达及其与临床病理参数之间的相关性。方法采用免疫组化法检测36例SCC、27例BCC和20例SK、10例正常人皮肤（normal skin，NS）中Ezrin、phos-Ezrin蛋白表达水平。结果①Ezrin、phos-Ezrin蛋白在NS、SK、BCC、SCC中的阳性表达率分别为20.0%，10.0%；25.0%，15.0%；66.7%，77.7%和91.3%，97.2%，各组之间比较差异有显著性（P0.01）。②Ezrin、phos-Ezrin蛋白表达水平与皮肤肿瘤的类型、恶性程度（SCC的病理分级）及淋巴结转移密切相关（R1，r1=0.87，0.89；R2，r2=0.80，0.86；R3，r3=0.89，0.91，P0.01）。结论Ezrin、phos-Ezrin阳性表达水平在SK、BCC、SCC组织中与皮肤肿瘤的类型、恶性程度（病理分级）和淋巴结转移有关，两者呈平行表达关系，联合检测可能成为预测皮肤恶性肿瘤转移及预后的重要指标。 关键词：Ezrin/phos-Ezrin；皮肤肿瘤；转移 中图分类号：R739.5文献标识码：A Expression and clinic significance of Ezrin and phosphorylated-Ezrin in skin squamous carcinoma,basal cell carcinoma and seborrheic keratosis WU Bin1,XIE Hong-fu2，ZHANG Jiang-lin2,LI Ji2 （1.Department of Dermatology,Affiliated Hospital,Xiangnan College,Chenzhou,Hunan 423000, P.R.China；2.Department of Dermatology,Xiangya Hospital,Central South University, Changsha,Hunan 410008,P.R.China） Abstract【:Objective】To approach the expression of Ezrin and phosphorylated-Ezrin(phos-Ezrin)in seborrheickeratosis(SK),basal cell carcinoma(BCC)and squamous cell carcinoma(SCC),and the relationship between themand the clinical pathological parameters.【Methods】Immunohistochemistry array was used to detect the expression of Ezrin,phos-Ezrin in 36 cases of SCC,27 cases of BCC and 20 cases of SK and 10 cases of normal skin.【Re－sults】①The positive ratios of Ezrin,phos-Ezrin in NS,SK,BCC,SCC were 20.0%,10.0%;25.0%,15.0%;66.7 %,77.7%;and 91.3%,97.2%,respectively.There was significant difference between each group(P0.05).②The expressions of Ezrin,phos-Ezrin were closely correlated to the type of skin tumors,malignant degree(pathological grading of SCC)and lymphatic metastasis(R 1=0.87,r 1=0.89;R 2=0.80,r 2=0.86;R 3=0.89,r 3=0.91;P0.05).【Conclusion】The expressions of Ezrin,phos-Ezrin in SK,BCC,SCC of skin tissue are closely related to the type of tumor,malignant degree an