长效药物治疗新.ppt

Features of Schizophrenia;;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;;MRI Schematic of Progression in Schizophrenia;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.; WHAT PART OF THE BRAIN TISSUE IS LOST IN SCHIZOPHRENIA ??;Atrophic Neuropil Changes in Schizophrenia;Shrinkage of the Brain in Schizophrenia:It’s in the Neuropil !;Copyright restrictions may apply.;Brain RepairIn Schizophrenia;NEUROPLASTICITY;Animal Studies of Neurogenesis with Antipsychotics;Animal Studies of Neurogenesis with Antipsychotics;OLFACTORY NEUROEPITHELIUM DATA;MRI Human Studies of Antipsychotics and Neuroplasticity;Effects of Antipsychotics on Neurotropic Factors in Schizophrenia;Differential Effects of Typical and Atypical Antipsychotics on Neurotropins in Schizophrenia;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Differential Effects of Typical and Atypical Antipsychotics on Neurotropins in Schizophrenia;THUS, UNLIKE CONVENTIONALS, ATYPICAL ANTIPSYCHOTICS HAVE BEEN SHOWN TO BE NEUROPROTECTIVE I.E. ATYPICALS CAN PREVENT PROGRESSIVE BRAIN TISSUE LOSS ASSOCIATED WITH PSYCHOSIS AND STIMULATE NEURITE EXTENSION, NEUROGENESIS AND CELL SURVIVAL ;Differential effects of long-term treatment with typical and atypical antipsychotics on NGF and BDNF levels in rat striatum and hippocampus;Whole-Brain Gray Matter MRI Volumes for Patients by Treatment Group and for Healthy Volunteers: Effects of Atypical VS. Typical antipsychotics (Baseline, Week 12, and Week 52) Lieberman JA et al: Arch Gen Psychiatry 2005 ;Risperidone in first-episode psychosis: A longitudinal, exploratory voxel-based morphometric study;Change in cerebral gray matter volumes with one month of antipsychotic treatment in patients hospitalized for acute exacerbation of chronic schizophrenia (no medication for 2 months)