卡络磺钠联合西咪替丁治疗上消化道出血的疗效观察.PDF

·460· 现代药物与临床 Drugs Clinic 第 32 卷 第 3 期 2017 年 3 月 卡络磺钠联合西咪替丁治疗上消化道出血的疗效观察 秦豫培，刘 鹏，郝良成，邹 灿，王 丹 湖北医药学院附属东风医院 消化内科，湖北 十堰 442000 摘 要：目的 观察卡络磺钠联合西咪替丁治疗上消化道出血的临床疗效。方法 选取 2015 年 1 月—2016 年 3 月于湖北医 药学院附属东风医院接受治疗的上消化道出血患者 78 例，随机分为对照组和治疗组，每组各 39 例。对照组给予西咪替丁注 射液，取 2 mL 用 5%葡萄糖注射液稀释后静脉推注，根据患者出血情况而定，最多每 6 小时静推 1 次。治疗组在对照组的 治疗基础上加用注射用卡络磺钠，60～80 mg 加入 5%葡萄糖液稀释后静脉滴注，1 次/d。两组治疗疗程均为 72 h。观察两组 的临床疗效和止血效果，比较两组治疗前后血小板的变化情况。结果 治疗后，对照组和治疗组的临床总有效率分别为 82.05%、94.87%；两组止血总有效率分别为 89.74%、97.44%，两组比较差异有统计学意义（P＜0.05）。治疗组的平均止血时 间短于对照组，两组比较差异有统计学意义（P＜0.05）。治疗后，治疗组患者血小板水平明显升高，高于对照组，两组比较 差异有统计学意义（P＜0.05）。结论 卡络磺钠联合西咪替丁治疗上消化道出血具有较好的临床疗效，止血效果较好，具有 一定的临床推广应用价值。 关键词：注射用卡络磺钠；西咪替丁注射液；上消化道出血；平均止血时间；血小板水平 中图分类号：R975 文献标志码：A 文章编号：1674 - 5515(2017)03 - 0460 - 04 DOI: 10.7501/j.issn.1674-5515.2017.03.024 Clinical observation of carbazochrome sodium sulfonate combined with cimitidine in treatment of upper gastrointestinal hemorrhage QIN Yu-pei, LIU Peng, HAO Liang-cheng, ZOU Can, WANG Dan Dongfeng Hospital Affiliated to Hubei University of Medicine, Shiyan 442000, China Abstract: Objective To observe the clinical efficacy of carbazochrome sodium sulfonate combined with cimitidine in treatment of upper gastrointestinal hemorrhage. Methods Patients (78 cases) with upper gastrointestinal hemorrhage in Dongfeng Hospital Affiliated to Hubei University of Medicine from January 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 39 cases. Patients in the control group were iv administered with Cimitidine Injcetion, 2 mL was diluted with 5% glucose injection. According to the hemorrhage, the patients were iv injected once every 6 h at most. Patients in the treatment gr