新型实验动物模型1是.ppt

新型实验动物模型;本次课应了解内容;Second thymus found in mice Mice commonly have more than one thymus gland, according to a research team that found small, previously unidentified thymus glands in the necks of laboratory mice. Although these results are not entirely unexpected, they may have important implications for the interpretation of immunology studies. ; The thymus, located in the thoracic cavity near the heart, is where T lymphocytes undergo their final stage of development .previous studies in mice have shown that removal of the thymus does not completely eliminate T-cell development, although they are often seen in human fetuses, cervical thymus glands are considered rare in adult humans and thought to be associated with pathologies.; During the course of immunological experiments, Hans-Reimer Rodewald of the university of Ulm (Germany)and his colleagues noticed small lymphoid-like organs in the necks of mice that they could no decisively identify as lymph nodes. they found that the mystery organs expressed thymus-specific genes and , when transplanted into mice deficient in T cells, produced functional T cells ;that contributed to an antibody response to hepatitis B antigen.the number of cervical thymus varied by strain. Researchers often remove the thoracic thymus in mice to study the immune system in the absence of T cells. The possibility that thymicomized mice retain he ability to produce T cells in a cervical thymus suggests that many previous studies may have to be reanalyzed. ;;;;英国给人猪混合胚胎研究开绿灯;英国给人猪混合胚胎研究开绿灯 ?????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? BBC网站上公布的人兽混合胚胎照片; 英国人类生殖与胚胎协会(HFEA)已经颁发许可，同意生成人猪混合胚胎用以研究心脏病疗法。该协会第三次颁发人兽杂交胚胎许可。HFEA发言人表示，正式批准沃里克大学临床医学研究院的申请，准许自7月1日起合成人猪混合胚胎，有效期为一年。沃里克大学该项研究课题带头人表示：这张新许可证使我们尝试通过人猪混合胚胎克隆出胚胎干细胞，后者在体内可以长成200倍大。;提取病人皮肤细胞，其中会含有某些心脏病突变基因(如心肌症，使心脏供血无力)，并将其注入已清除染色体猪卵泡中，生成晶胚并从中提取胚胎干细胞，以研究