临床调查的.pdf

Journal of the Formosan Medical Association (2011) 110, 600e606 ava ilable at www.science di rect .com j o u r n al h o m ep a g e : w w w . j f m a - o n l i n e . c o m ORIGINAL ARTICLE A hospital-based study of clinical and genetic features of Crohn’s disease Shu-Chen Wei a, Yen-Hsuan Ni b, Hwai-I Yang c, Yi-Nin Su d, Ming-Chu Chang a, Yu-Ting Chang a, Ming-Jium Shieh e, Cheng-Yi Wang a, Jau-Min Wong a,* a Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan b Department of Pediatrics, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan c Genomics Research Center, Academia Sinica, Taipei, Taiwan d Department of Genetic Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan e Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan Received 3 May 2010; received in revised form 17 June 2010; accepted 12 October 2010 KEYWORDS Background/Purpose: The aim of this study was to gain a better understanding of the current ATG16L1 ; incidence of Crohn’s disease (CD) in Taiwan and examine its clinical/genetic characteristics Crohn’s disease; because there has been a trend toward increased diagnosis in the Asia-Pacific area. The genetic genetics; background seen in CD cases in Taiwan seems to be different from that in Western countries. Taiwan; Methods: By reviewing the database in the National Taiwan University Hospital, CD patients TNFSF15 were identified by clinical, endoscopic, and imaging findings. The clinical characteristics were recorded and analyzed. DNA was extracted