阿戈美拉汀与度洛西汀治疗抑郁症患者的疗效分析.docVIP

阿戈美拉汀与度洛西汀治疗抑郁症患者的疗效分析 2016年06月 第28卷 半月刊 第12期 中国民康医学 MedicalJournalofChinesePeople#39;sHealth Jun,2016 Vol.28 Semimonthly No.12 【论 著】 陈 恳1,彭红星2,黄兴东2 表法分为研究组和对照组,每组各54例。研究组患者单一使用阿戈美拉汀治疗;对照组患者单一使用度洛西汀治疗。在基线、2周末、4周末、8周末,采用汉密顿抑郁量表(HAMD)和不良反应症状量表(TESS)对两组患者进行疗效和安全性评估。结果:在治疗后8周末,研究组和对总分与治疗前比较均显著下降(Plt;0.01),两组间比较差异无统计学意义(Pgt;0.05)。研究组患者的不良反应与对照组比较,得分及分布差异均无统计学意义(Pgt;0.05)。结论:阿戈美拉汀治疗抑郁症患者的疗效与度洛西汀相当。 照组患者的临床治疗有效率分别为72.2%和63.0%,两组患者比较,差异无统计学意义(Pgt;0.05)。治疗后第2、4、8周末,两组患者的HAMD (1.重庆市精神卫生中心,重庆 401147;2.重庆市三峡民康医院) 【关键词】 阿戈美拉汀;度洛西汀;抑郁症 doi: 10.3969/j.issn.1672-0369.2016.12.002 中图分类号: R749.4+1 文献标识码: A 文章编号: 1672-0369(2016)12-0004-04 CHENKen1,PENGHongxing2,HUANGXingdong2 EfficacyanalysisofAgomelatineversusDuloxetineondepressivedisorder (1.ChongqingMentalHealthCenter,Chongqing404300,China;2.ChongqingSanxiaMinkangHospital) meetingICD-10criteriaofdepressivedisorderswererandomizedintostudygroup(n=54,treatedwithAgomelatinefor8weeks)andcontrolgroup(n=54,treatedwithDuloxetinefor8weeks).AllpatientswereassessedwithHamiltondepressionscale(HAMD)andtreatmentemergentsymptomscale(TESS)atbaselineandtheendofthe2nd,4th,8thweekofthetreatmenttoevaluatetheefficacyandsafety,respectively.Results:Therewasnosignificantdifferenceinresponserateattheendofthe8thweekbetweenstudygroupgt;0.05).Therewerenosignificantdifferencesinfrequencyandscoreofsideeffectsbetweenstudygroupandcontrolgroup(Pgt; 【Keywords】Agomelatine;Duloxetine;Depressivedisorder andcontrolgroup(72.2%vs63.0%%,Pgt;0.05).ThescoresofHAMDinbothgroupdecreasedsignificantlyattheendofthe2nd,0.05).Conclusions:ComparedwithDuloxetine,Agomelatinehassimilartherapeuticeffectsinthetreatmentofpatientswithdepres-sivedisorders. 【Abstract】 Objective:ToevaluateefficacyofAgomelatineversusDuloxetineondepressivedisorder.Methods:108patients 4th,and8thweekwhencomparedwiththebaseline(Plt;0.01),buttherewasalsonosignificantdifferencebetweenthetwogroups(P 抑郁症是最常见的精神障碍之一,是由各种原