头孢他定椎管内持续给药治疗化脓性脑膜炎(附首例报告).pdfVIP

.228. 南方医科大学学报。Sou由 MedUniv) 2008;28(2) 头子包他定推管内持续给药治疗化服性脑膜炎(附首例报告) 尹恕，吕回明，刘晓加，王群，潘速跃(南方医科大学南方医院神经内科，广东广州 510515) 摘要:目的探讨头抱他定椎管内持续给药治疗化服性脑膜炎的可行性。方法临床确诊 l 例无色杆菌属感染的化在性 脑膜炎，给予静脉注射头子包他定 4 gld ，并进行腰大池置管外引流。 3d 后在静脉注射头抱他定的同时经腰大池置管给予 头子包他定榷管内持续给药。 .2 gld,3 d 后症状明显缓解，拔除腰大池管，继续静脉注射头子包他定 1 周。结果头泡他定椎 管内持续给药同时静脉注射疗效明显好于??纯静脉注射，曾经尝试鞠内注射头抱他定患者无法耐受。结论头抱他定椎 管内持续给药治疗化服性脑膜炎去全有效。 关键词:化服性脑腹炎;头抱他定:椎管内持续给药 中图分类号:R5 15.2 文献标识码 :B 文章编号: 1673-4254(2008)02-0228-02 Continuous intraspinal ceftazidime administration in a case for treatment of purulent meningitis YIN Jia, Lü Ti阻-ming ， LIU Xiao-jia, WANG Qun, PAN Su..;沪Je Department ofNeurolo町， Nan鱼ng Hospítal, Southem Medícal Uníversi纱， Guangzhou 510515, China Abs仕act: Objective To investigate the feasibility of continuous intraspinal ceftazidime: adminis回tion for treatment of purulent meningitis due 10 A chroTTWbacter infection. Methods A patíent with established diagnosis of purulent meningitis due ω AchroTTWbacter infection was admitted, who failed to respond fàvorablyωa 3-day ceftazidime treatment administered intravenously. Continuous in回spinal ce企但idime administration at 也e dose of 0.2 gld was then a忧emp能d through a catheter placed in the cisterna magna in addition ωm田venous ceftazidime for 3 days, which resulted in obvious relief of the S泸npωms. The catheter was subsequently withdrawn, and the patient received 也r也町 treatment with additional intravenous C宿 ftazidime for a week. ResuJts The s归nptoms of purulent meningitis was significantly improved after a 3-day continuous intraspinal ceftazidime adrninistr就ion ， and the pa出nt was eventually cured