布地奈德+孟鲁司特治疗轻中度持续哮喘的临床疗效观察.pdfVIP

布他祟德、+孟鲁司持。台疗轻中皮持续哮喘的临和守放况察 黄辛武* (湖北省咸宁市中心医院，湖北咸宁 4371 ∞) 中固分类号 R974 +.3 文献标志码 B 文章编号 1672 -2124(2013)06 -0553 -03 摘 要 目的:探讨布地奈德在轻中度持续哮喘治疗中的临床应用价值。方法:将 2010 年 6 月 2011 年 6 月收治的 l ∞例轻中 度持续哮喘患者以随机抽样法分成观察组与对照纽各 50 例，对照纽采用孟鲁司特纳口服治疗，观察组采用布地奈德+孟鲁司特 联合治疗。观察比较治疗后 H且间患者临床疗效、不良反应发生情况、平均住院时间与呼吸困难、喘息、哮鸣音、咳嗽消失时间及 肺功能、哮喘症状评分。结果:观察组总有效率为 96. 0% ( 48/50) ，对照组总有效率为 76. 0% (38/50) ，观察组患者的临床疗效显 著优于对照纽 (P 0. 05); 观察组患者的平均住院时间与呼吸困难、喘息、哮鸣音、咳嗽消失时间均明显少于对照纽 (P 0. 05); 观 察组患者的肺功能改善程度和哮喘症状评分均明显优于对照组 (P O. 05); 观察纽患者心肺功能参数改善明显优于对照纽 (P 0. 05); 观察组与对照组在治疗费用和抗菌药物使用数量、时间方面比较，差异有统计学意义 (P 0. 05) 。结论:临床应用布 地奈德+孟鲁司特联合治疗轻中度持续哮喘的效果良好。 关键词 布地奈德;孟鲁司特;哮喘;临床疗效 Clinical Efticacy of Budesonide Plus Montelukast for Mild-to-Moderate Persistent Asthma HUANG Xin-wu (Huhei Xianning Municipal Central Hospital , Huhei Xianning 437100 , China) ABSTRACT OBJECTIVE: To investigate the clinical application value of budesonide in the treatment of mild-to? moderate persistent asthma. METHODS: 1 ∞ patients with mild-to-moderate continuous asthma treated in our hospital from June 2010 to June 2011 were randomly assigned to receive either montelukast sodium alone (control group) or montelukast sodium plus budesonide (experimental group) of 50 cases each. 咀le two groups were compared with regard to clinical efficacy , adverse reactions , average length of hospital stay , time to extinction of dyspnea , wheeze , cough and wheezing rale , lung function and asthma symptom scores. RESULTS: 咀le total effective rate in the experimental group was significantly higher than in the control group [96. 0% (48/50) vs. 76. 0% (38/50 , P O. 05) ; the average length of hospital stay , time to distinction of dyspnea , wheeze , cough and wheezing rale were significantly less in the experimental