常见垂体疾病与骨质疏松的研究进展.pdfVIP

安徽医药 Anhui Medical αnd Pharmα ceuticalloumal 2015 Nov;19( 1l) .2053. 常见垂体疾病与骨质疏松的研究进展 李晨曦，章秋 (安徽医科大学第一附属医院内分泌科，安徽合肥 230022) 摘要:垂体作为人体重要的内分泌器官，可分泌数种激素参与各项生命活动的调节。下丘脑一垂体疾病众多，外伤、肿瘤、炎 症等因素均可造成垂体激素分泌和代谢异常，产生相关临床症状。近年来研究表明，垂体疾病是继发性骨质疏松的重要病因 之一，生长激素、泌乳素、促肾上腺皮质激素、促性腺激素等腺垂体激素参与了骨质疏松的发生和发展，现就常见垂体疾病与 骨质疏松的研究进展予以综述。 关键词:垂体疾病;骨密度;骨质疏松;垂体激素 doi: 10. 3969/j. issn. 1 侃)9 -6469.2015.1 1.∞4 Research Advances in Common Pituitary Diseases and Osteoporosis LI Chen -x? ,ZHAN G Qiu (V，甲αrtment of Endocrinology ,The First Affiliated Hospitα1 of Anhui Medical University , U价 i 230022 , China ) Abstract: Pituit町， as a critical endocrine organ , releases a few hoπnones to participate in the regulation of nonnal life activities. ηJere are various hypothalamic-pituitary diseases , and the abnonnal secretion and metabolism of pituitaηhonnones caused by trauma , tumor or inflammation could lead to a series of clinical symptoms. Recent studies have demonstrated that pituitary diseases are an im? portant cause of secondary osteoporosis. Growth honnone (GH) , prolactin (PRL) , adrenocorticotrophic honnone (ACTH) , and go? nadotrophic honnone (GTH) play vi恒1 roles in the onset and development of osteoporosis. 币Jis article reviews the pro伊ss of common pituitary dise咀ses and osteoporosis. Key words: pituitary diseases; bone mineral density; osteoporosis; pituitary honnones 骨质疏松症( osteoporosis, OP) 是以骨量和骨 (growth hormone , GH) 分泌过多导致全身软组织、骨 强度减少、骨组织微结构破坏为特征，致使骨的脆 和软骨过度增生，进而引起???容改变、手足肥厚、皮 性增加及易于发生骨折的一种代谢性骨髓疾病 [1] 。 肤粗糙、器官增大、骨关节活动障碍等临床表现的 骨质疏松按病因可分为原发性和继发性两类，由明 一类疾病 [3JO 据统计 959