3种中药辨证方治疗慢性肾炎蛋白尿的临床分析.PDFVIP

3种中药辨证方治疗慢性肾炎蛋白尿的临床分析 ＊ 裘雯慧 ，王洲峰（慈溪市第二人民医院，浙江慈溪 315315） 中图分类号 R696；R277.5 文献标志码 A 文章编号 1001-0408（2014）27-2575-03 DOI 10.6039/j.issn. 1001-0408.2014.27.27 摘 要 目的：研究脾气肾阴两虚证治疗方、脾气肾阳两虚证治疗方和瘀血证治疗方对慢性肾炎蛋白尿患者尿蛋白定量、血浆纤 维蛋白原含量、尿表皮生长因子和尿纤维蛋白含量的影响，同时监测肾功能，以评价三者的临床治疗效果。方法：将60例慢性肾 炎蛋白尿患者随机均分成3组。观察3组患者治疗前及治疗8周后蛋白尿治疗效果，测定尿纤维素蛋白降解产物含量、24h 尿蛋 白定量、血浆纤维蛋白原含量、尿表皮生长因子含量和血尿素氮及血肌酐含量。结果：3种中药辨证方治疗均能明显降低尿纤维 素蛋白降解产物含量、24h 尿蛋白定量、血浆纤维蛋白原含量、尿表皮生长因子和尿纤维蛋白的水平，3组间作用比较差异无统计 学意义（P ＞0.05）；同时治疗后与治疗前比较，患者血尿素氮、血肌酐含量差异无统计学意义（P ＞0.05）。结论：初步认为3种中药 辨证方对于慢性肾炎蛋白尿具有良好的治疗效果，且无明显的肾脏损伤。该结论有待更多临床病例研究验证。 关键词 中药辨证方；肾炎；蛋白尿；尿蛋白定量；尿表皮生长因子 Preliminary Study on 3Kinds of Syndrome-differentiation of TCM in the Treatment of Chronic Nephritis Al- buminuria QIU Wen-hui ，WANG Zhou-feng （Cixi Second People ’s Hospital ，Zhejiang Cixi 315315，China ） ABSTRACT OBJECTIVE ：To study the effects of 3 kinds of syndrome-differentiation preparations of TCM including spleen-qi and kidney-yin deficiency syndrome ，spleen-qi and kidney-yang deficiency syndrome and blood stasis on the quantification of urine protein ，the contents of plasma fibrinogen ，urine epidermal growth factor and urine hemaleucin ，chronic nephritis and monitor the kidney function and evaluate therapeutic efficacy of them. METHODS ：60patients with chronic nephritis proteinuria were randomly divided into 3 groups with 20 cases in each group. 24 h urine protein ，plasma fibrinogen ，urine epidermal growth factor and urine hemaleucin of 3 groups were observed before treatment and after 8 weeks of treatment ，and renal function as blood urea nitrogen and serum creatinine was monitored during treatment. RESULTS ：3kinds of syndrome-differentiation preparations of TCM could de- crease urinary fibrin degradation production ，urine protein ，plasma fibrinogen ，urine epidermal growth factor and urine hemaleucin significantly after treatment ；there was no sta