哌罗匹隆辅助治疗老年抑郁症的临床观察.PDFVIP

哌罗匹隆辅助治疗老年抑郁症的临床观察 ＊ 阳中明 ，张 恩（芜湖市第四人民医院，安徽芜湖 241002） + 中图分类号 R971.43；R749.053 文献标志码 A 文章编号 1001-0408（2015）23-3266-02 DOI 10.6039/j.issn. 1001-0408.2015.23.33 摘 要 目的：观察哌罗匹隆辅助治疗老年抑郁症的疗效和不良反应。方法：将64例老年抑郁症患者按就诊顺序随机分为帕罗 西汀合并哌罗匹隆组（合用组）和帕罗西汀组（单用组），各32例。两组患者均服用帕罗西汀20～40mg/d ，合用组同时加用哌罗匹 隆4～8mg/d 。治疗8周后采用汉密尔顿抑郁量表（HAMD ）、临床总体印象量表（CGI-SI ）评定疗效，药物副反应量表评价不良反 应，并进行组间比较。结果：治疗8周末合用组和单用组的有效率分别为75.0％、50.0％，组间比较差异有统计学意义（P ＜0.05）； 组间HAMD 、CGI-SI 评分比较差异亦有统计学意义（P ＜0.05）。两组不良反应发生率相当，差异无统计学意义（P ＞0.05）。结论： 小剂量哌罗匹隆对帕罗西汀治疗老年抑郁症具有增效作用，且未增加不良反应、安全性好。 关键词 哌罗匹隆；帕罗西汀；联合用药；老年抑郁症 Clinical Observation of Perospirone in the Treatment of Elderly Depression YANG Zhong-ming ，ZHANG En （Wuhu 4th People ’s Hospital ，Anhui Wuhu 241002，China ） ABSTRACT OBJECTIVE ：To observe therapeutic efficacy and side effect of perospirone in the treatment of elderly depression. METHODS ：64 elderly patients with depression were randomly divided into paroxetine combined with perospirone group （drug combination group ）and paroxetine group （single drug group）with 32 patients in each group. Both groups were given paroxetine 20-40 mg/d ，and drug combination group was additionally given perospirone 4-8 mg/d. HAMD and CGI-SI were adopted to evalu- ate therapeutic efficacy after 8 weeks treatment ，and side effect was evaluated with TESS scale ；those were compared between 2 groups. RESULTS ：After 8 weeks treatment ，the effective rate of drug combination group and single drug group were 75.0％and 50.0％；there was statistical significance （P ＜0.05）. There was statistically significant difference in HAMD and CGI-SI scores be- tween two groups （P ＜0.05）. There was no statistically significant difference in the incidence of ADR between 2 groups （P ＞0.05）. CONCLUSIONS ：Small-dose of perospirone can improve therapeutic efficacy of paroxetine in the treatme