布地奈德、沙丁胺醇联合异丙托溴铵雾化吸入在慢性阻塞性肺疾.PDFVIP

布地奈德、沙丁胺醇联合异丙托溴铵雾化吸入在慢性阻塞性肺疾 病急性加重期中应用的临床观察 ＊ 王 芳 ，张永建，陆娟英（浙江省海盐县中医院重症监护室，浙江海盐 314300） 中图分类号 R563 文献标志码 A 文章编号 1001-0408（2014）44-4150-04 DOI 10.6039/j.issn. 1001-0408.2014.44.07 摘 要 目的：观察布地奈德、沙丁胺醇联合异丙托溴铵雾化吸入在慢性阻塞性肺疾病急性加重期（AECOPD ）中应用的临床疗效 和安全性。方法：将64例AECOPD 患者随机均分为研究组和对照组。对照组患者给予2ml 布地奈德和1ml 沙丁胺醇雾化吸入治 疗，研究组患者在此基础上加入2ml 异丙托溴铵雾化吸入治疗。两组患者均每日2次给药，疗程均为7d。对比两组患者治疗前 后的肺功能指标和血气指标变化，观察临床疗效和不良反应情况。结果：治疗前两组患者的肺功能指标和血气指标比较，差异均 无统计学意义（P ＞0.05）；治疗后两组患者的肺功能指标和血气指标均较治疗前显著改善，且研究组患者均显著优于对照组，组内 及组间比较差异均有统计学意义（P ＜0.01）。研究组患者治疗总有效率显著高于对照组（P ＜0.05）。两组患者均未出现严重不良 反应，不良反应发生率比较差异无统计学意义（P ＞0.05）。结论：布地奈德、沙丁胺醇联合异丙托溴铵雾化吸入治疗AECOPD 较未 加用异丙托溴铵的疗效更显著，安全性相似。 关键词 慢性阻塞性肺疾病急性加重期；布地奈德；沙丁胺醇；异丙托溴铵；雾化吸入 Clinical Observation of Aerosol Inhalation of Budesonide and Ventolin Combined with Ipratropium Bro- mide for Acute Exacerbation of COPD WANG Fang ，ZHANG Yong-jian ，LU Juan-ying （Intensive Care Unit ，Haiyan County Hospital of TCM of Zheji- ang Province ，Zhejiang Haiyan 314300，China ） ABSTRACT OBJECTIVE ：To observe the clinical efficacy and safety of aerosol inhalation of budesonide and ventolin combined with ipratropium bromide for acute exacerbation of COPD （AECOPD ）. METHODS ：A total of 64patients with AECOPD were ran- domly divided into control group and study group. Control group was treated with aerosol inhalation of budesonide 2ml and vento- lin 1ml twice a day. Study group was additionally treated with aerosol inhalation of ipratropium bromide 2ml twice a day on the ba- sis of control group. Treatment course of 2groups lasted for 7d. The lung function and blood gas index of 2groups were compared before and after treatment ，and clinical efficacy and ADR were observed in 2 groups. RESULTS ：There was no statistical signifi- cance in lung function index and blood gas index between 2 groups before treatment （P ＞0.05）. Compared with before treatment ， lung function index and