中西医结合分期综合治疗痛风性关节炎的随机对照临床研究.docVIP

　　中西医结合分期综合治疗痛风性关节炎的随机对照临床研究 作者：王一飞, 李伯华, 张明, 徐文彬, 周蓉, 周敏 【摘要】 研究中西医结合分期论治的综合 治疗 方案防治痛风性关节炎的临床疗效，探索痛风性关节炎更安全、有效、合理的治疗方案。方法：将166例痛风患者随机分成3组：中药组58例、西药组56例和中西药组52例，连续观察12周。急性期中药组予虎杖痛风颗粒、金黄膏，西药组予双氯芬酸钠双释放肠溶胶囊；间歇期中药组予茵连痛风颗粒，西药组予苯溴马隆片或别嘌呤醇片；中西药组予中药组和西药组药物。观察整个治疗期间临床症状积分、血尿酸、显效时间、复发率、愈显率和不良反应发生率等指标。结果：在急性期，3组愈显率和显效时间比较，差异无统计学意义；3组临床症状积分和血尿酸水平降低，但差异无统计学意义。在间歇期，西药组、中西药组血尿酸水平明显降低，而中药组血尿酸水平虽有下降趋势，但差异无统计学意义。中药组复发率为12.07%，西药组为26.79%，中西药组为9.62%；中药组复发时平均症状积分为（10.00±3.61）分，西药组为（12.38±1.85）分，中西药组为（10.75±1.89）分。3组复发率和复发时的症状积分比较，差异有统计学意义。中药组不良反应发生率为3.45%，西药组为21.43%，中西药组为15.38%，3组间不良反应发生率比较，差异有统计学意义。结论：中西医结合分期综合防治方案既能安全、有效地控制痛风性关节炎急性期症状，恢复关节功能，又能有效地控制间歇期血尿酸水平，预防急性发作，减轻不良反应。 【关键词】 痛风性关节炎; 中西医结合疗法; 临床研究; 随机对照试验 　　Objective: To evaluate the clinical therapeutic effect of the bination therapy of traditional Chinese and ethods: One hundred and sixtysix cases of gouty arthritis ly, 58 cases in traditional Chinese drug (TCD)treated group, 56 cases in )treated group and 52 cases in TCD plus treated group. They ent, and patients in treated group dual release entericcoated capsules. In the intermission, patients in TCDtreated group arone or allopurinol. Patients in TCD plus treated group ptom score and blood uric acid (BUA) level easured. The effect initiating time, relapse rate, efficacy rate and the incidence rate of adverse effects e among the three groups in the acute stage. The clinical symptom score and BUA level ission, BUA level in the treated group and TCD plus treated group ong the three groups (Plt;0.05). The relapse rate ptom scores during recurrence in the three groups edicines based on the stage of disease can control the symptoms of gouty arthritis in the acute stage, improve joint function, and can control the BUA level during the intermission, prevent recurrence and relieve the adverse effects. 　　Keyedicine therapy; clinical research; randomized controlled trial 痛风性关节炎属于非根治性疾病，需要长期饮食控制和药物治疗，而目前临床上尚缺乏一个合理、规范的治疗方案，所采用的治疗药物若长期服用都会对人体多个系统产生不良影响，因此积极研究、开发新的安全有效的治疗药物