早期谷氨酰胺强化肠外营养对危重患者保护机制的研究_倪海滨.pdf

·486 · 2008 6 28 6　ChinJCritCareMed, June2008, Vo.l28, No.6 　　 　 倪海滨, 　张　铮, 　秦海东 :(No.06NMUN066 ) :2 10006, ICU :(1970 -),, , , :。 　　[]　　(Gln) , 。　 ICU 44 , Gln, 22 。 -1 -1 、, Gln Gln0.4 g·kg ·d, 7 d。 70(HSP70 )、Gln、、。　 Gln、HSP70 (P0.05 )。 Gln、HSP70 , ; Gln、HSP70 (P 0.01), Gln、HSP70 (P0.01)。 Gln HSP70 (r0.65, P 0.001)。 (P 0.05 )。 CD3、 CD4、CD4 /CD8 (P0.05 )。 　 Gln, HSP70 。 []　;　;　 70;　 []　R459.3　[]　A　[]　1002-1949(2008)06-0486-03 Effectofearlyenrichedparenteralglutamineonheatshockprotein70 (HSP70 )expressionincriti- calpatients　NIHai-bin, ZHANGZheng, QINHai-dong.EmergencyICU, NanjingFirstHospitalAf- filiatedtoNanjingMedicalUniversity, Nanjing2 10006, China [ Abstract]　Objective　Toevaluatetheeffectofearlyparenteralglutamine(Gln)administration onheatshockprotein(HSP70 )expressionandclinicaloutcomeincriticalpatient.sMethods　44 pa- tientswithparenteralnutrition(PN)formorethan7 day,sadmittedtoemergencyintensivecareunit (EICU)andneurosurgicaldepartmentwererandomlydividedintotwogroup,sonewasthecontrolgroup, theotherwastheGlntreatmentgroup(n22, ineachgroup).PatientsintwogroupsreceivedPNand enteralnutrition(EN).Inaddition, Gln0.4 g/kgperdaywasgiventopatientsinGlntreatmentgroupfor 7 day.sSerumHSP70 andGlnconcentrationsweremeasuredatadmissionand7 daysafterthenutritional supplemen.tClinicaloutcomesbeforeandaftertreamten,tandthepercentofCD3, CD4 cellswereob- served.Results　TherewerenosignificantchangesinserumHSP70 andGlnlevelbetweencontrolgroup andGlntreamtentgroupbeforethetreamtent(bothP0.05 ).Afterthetreatmen,tserumHSP70 and Glnlevelincontrolgroupincreasedslightly, buttherewasnostatisticaldifferences;theyinGlntreamtent groupwereobviouslyhigher(bothP0.01), andtherewerestatisticaldifferenceinserumHSP70 and Glnlevelbetweencontrolgroupan